Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Localized tongue amyloidosis: a single institutional case series. Otolaryngol Head Neck Surg 2013 Aug;149(2):240-4



Pubmed ID




Scopus ID

2-s2.0-84884195461   11 Citations


OBJECTIVE: Review Mayo Clinic experience of localized tongue amyloidosis.

STUDY DESIGN: Case series with retrospective chart review.

SETTING: Academic medical center.

SUBJECTS AND METHODS: Cases of localized tongue amyloidosis were identified from the dysproteinemia database at the Mayo Clinic in Rochester, Minnesota. Electronic records were reviewed with focus on presenting symptoms, laboratory results (ie, serum or urine immunoelectrophoresis, bone marrow biopsy, and fat aspirate analysis), treatment modality, and status of disease at follow-up.

RESULTS: Six cases of localized tongue amyloidosis presented to the Mayo Clinic between 1969 and 2011. Mean patient age was 69 years (range, 43-90). Patients presented with asymptomatic tongue mass(es). Biopsy of the tongue mass in all patients showed amyloid on Congo red stains. Work-up for systemic amyloidosis, including bone marrow biopsy, fat aspiration, and serum and urine protein immunoelectrophoresis, was negative for all 6 patients, nor was there other organ involvement. Two patients underwent resection of the lesions, and the remaining patients elected for observation. Recurrence requiring repeat excision occurred in 1 of the patients that underwent resection. Repeat evaluation for systemic involvement was performed in 3 patients 1 to 3 years after the initial diagnosis. None of these patients went on to develop systemic involvement.

CONCLUSIONS: Localized tongue amyloidosis remains a rare diagnosis and requires exclusion of systemic involvement. Localized lesions may be observed or resected; however, recurrence may occur with resection. Patients with localized tongue amyloidosis do not appear to be at increased risk of developing systemic involvement.

Author List

O'Reilly A, D'Souza A, Lust J, Price D


Anita D'Souza MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged, 80 and over
Diagnosis, Differential
Follow-Up Studies
Immunoglobulin Light-chain Amyloidosis
Magnetic Resonance Imaging
Middle Aged
Prospective Studies
Time Factors
Tongue Diseases
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a