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Regulation of antiviral CD8 T-cell responses. Crit Rev Immunol 2013;33(6):477-88

Date

11/26/2013

Pubmed ID

24266346

Pubmed Central ID

PMC4729194

DOI

10.1615/critrevimmunol.2013007909

Scopus ID

2-s2.0-84885207420   5 Citations

Abstract

A balanced immune response to a viral pathogen leads to clearance of the virus while limiting immune mediated pathology. Control of this process occurs at all stages of the immune response, including during the induction of an antiviral response, clearance of virally infected cells, and the resolution of this response. Regulation of antiviral immune response is further modified when the immune system fails to clear the pathogen and by the nature of chronic infection itself. A number of processes have been implicated in the regulation of antiviral immune responses, such as the limitation of viral antigen load by interferons, apoptosis through cytokine withdrawal or Fas-mediated killing, and control of these responses by regulatory T cells. This review addresses several of these mechanisms.

Author List

Kulinski JM, Tarakanova VL, Verbsky J

Authors

Vera Tarakanova PhD Associate Professor in the Microbiology and Immunology department at Medical College of Wisconsin
James Verbsky MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Antigens, Viral
CD8-Positive T-Lymphocytes
Humans
Immunomodulation
T-Lymphocytes, Regulatory
Virus Diseases
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a