Regulation of antiviral CD8 T-cell responses. Crit Rev Immunol 2013;33(6):477-88
Date
11/26/2013Pubmed ID
24266346Pubmed Central ID
PMC4729194DOI
10.1615/critrevimmunol.2013007909Scopus ID
2-s2.0-84885207420 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
A balanced immune response to a viral pathogen leads to clearance of the virus while limiting immune mediated pathology. Control of this process occurs at all stages of the immune response, including during the induction of an antiviral response, clearance of virally infected cells, and the resolution of this response. Regulation of antiviral immune response is further modified when the immune system fails to clear the pathogen and by the nature of chronic infection itself. A number of processes have been implicated in the regulation of antiviral immune responses, such as the limitation of viral antigen load by interferons, apoptosis through cytokine withdrawal or Fas-mediated killing, and control of these responses by regulatory T cells. This review addresses several of these mechanisms.
Author List
Kulinski JM, Tarakanova VL, Verbsky JAuthors
Vera Tarakanova PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinJames Verbsky MD, PhD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsAntigens, Viral
CD8-Positive T-Lymphocytes
Humans
Immunomodulation
T-Lymphocytes, Regulatory
Virus Diseases
