Medical College of Wisconsin
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Epicardial GATA factors regulate early coronary vascular plexus formation. Dev Biol 2014 Feb 01;386(1):204-15

Date

01/02/2014

Pubmed ID

24380800

Pubmed Central ID

PMC3962664

DOI

10.1016/j.ydbio.2013.12.033

Abstract

During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The current study was conducted to investigate the molecular mechanisms by which the epicardium controls coronary vasculogenesis, focusing on the role of epicardial GATAs in establishing the endothelial plexus during early coronary vasculogenesis. To address the role of epicardial GATAs, we ablated GATA4 and GATA6 transcription factors specifically from the mouse epicardium and found that the number of endothelial cells in the sub-epicardium was drastically reduced, and concomitant coronary vascular plexus formation was significantly compromised. Here we present evidence for a novel role for epicardial GATA factors in controlling plexus formation by recruiting endothelial cells to the sub-epicardium.

Author List

Kolander KD, Holtz ML, Cossette SM, Duncan SA, Misra RP

Author

Ravindra P. Misra PhD Dean, Professor in the Biochemistry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cell Differentiation
Cell Proliferation
Coronary Vessels
Crosses, Genetic
Endothelium, Vascular
GATA4 Transcription Factor
GATA6 Transcription Factor
Gene Expression Regulation, Developmental
Genotype
Heart
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myocardium
Pericardium
Signal Transduction
Time Factors