Faculty Collaboration Database

Low CA1 spine synapse density is further reduced by castration in male non-human primates. Cereb Cortex 2004 May;14(5):503-10

Date

04/01/2004

Pubmed ID

15054066

DOI

10.1093/cercor/bhh012

Scopus ID

2-s2.0-2342579510 (requires institutional sign-in at Scopus site)   72 Citations

Abstract

The hippocampus plays a major role in learning and memory and its morphology and function are readily affected by gonadal hormones in female non-human primates. We sought to determine whether the gonads also affect pyramidal cell spine synapse density in the CA1 hippocampal area of male primates. Unbiased electron microscopic stereological calculations were performed to determine the volumetric density of pyramidal cell spine synapses and semiquantitative analyses on the surface density of glial fibrillary acidic protein-containing glia processes and the diameter of pyramidal cell apical dendrites in the CA1 area of intact and orchidectomized (1 month) St Kitts vervet monkeys (Chlorocebus aethiops sabaeus). The volumetric density (number of spine synapse/ micro m(3)) of spine synapses was significantly lower (40%) in the gonadectomized animals than in control monkeys; conversely, the density of glia processes was significantly higher (15%) and the diameter of dendritic shafts located in this area was also larger (30%) in the orchidectomized animals than in the controls. Strikingly, when compared to female values, intact male primates had lower spine synapse densities than either intact or ovariectomized females. Since the primate hippocampus is very similar to that of a human's, the present observations suggest that physiological levels of circulating androgen hormones are necessary to support normal spine synapse density in the CA1 stratum radiatum of human male hippocampus.

Author List

Leranth C, Prange-Kiel J, Frick KM, Horvath TL

Author

Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Animals
Cell Count
Dendrites
Humans
Male
Orchiectomy
Pyramidal Cells
Reference Values
Synapses