D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiol Aging 1994;15(2):207-13
Date
03/01/1994Pubmed ID
7838293DOI
10.1016/0197-4580(94)90114-7Scopus ID
2-s2.0-0028324172 (requires institutional sign-in at Scopus site) 122 CitationsAbstract
D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. The present experiment examines the behavioral effects of D-cycloserine on cognitive deficits in male Fischer-344 rats, 24 months old. Rats 24 months old (n = 42) received either vehicle or one of 3 doses of D-cycloserine prior to testing. Young rats, 4 months old (n = 13), received vehicle prior to testing. Place discrimination and repeated acquisition were tested in the water maze and a variety of sensorimotor tasks were given. Aging impaired performance in all tasks. D-cycloserine improved performance in place discrimination and repeated acquisition. No doses affected sensorimotor function. These results support the hypothesis that D-cycloserine has cognition enhancing properties and that it may be useful in treating disorders involving cognitive impairment.
Author List
Baxter MG, Lanthorn TH, Frick KM, Golski S, Wan RQ, Olton DSAuthor
Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AgingAnimals
Cognition
Cycloserine
Discrimination Learning
Male
Maze Learning
Memory
Psychomotor Performance
Rats
Rats, Inbred F344
Space Perception
