Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. J Pediatr 2007 Feb;150(2):140-5

Date

01/24/2007

Pubmed ID

17236890

DOI

10.1016/j.jpeds.2006.08.028

Scopus ID

2-s2.0-33846198883   117 Citations

Abstract

OBJECTIVES: To assess the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]-DOPA) PET scans to diagnose focal versus diffuse disease and to localize focal lesions in infants with congenital hyperinsulinism.

STUDY DESIGN: Twenty-four infants with hyperinsulinism unresponsive to medical therapy were studied. Patients were injected intravenously with [18F]-DOPA, and PET scans were obtained for 1 hour. Images were coregistered with abdominal CT scans.

RESULTS: The diagnosis of focal or diffuse hyperinsulinism was correct in 23 of the 24 cases (96%) and equivocal in 1 case. [18F]-DOPA PET identified focal areas of high uptake of radiopharmaceutical in 11 patients. Pathology results confirmed that all 11 had focal adenomatosis, and the locations of these lesions matched the areas of increased [18F]-DOPA uptake on the PET scans in all of the cases.

CONCLUSIONS: [18F]-DOPA PET scans were 96% accurate in diagnosing focal or diffuse disease and 100% accurate in localizing the focal lesion. These results suggest that [18F]-DOPA PET imaging should be considered in all infants with congenital hyperinsulinism who need to have pancreatectomy.

Author List

Hardy OT, Hernandez-Pampaloni M, Saffer JR, Suchi M, Ruchelli E, Zhuang H, Ganguly A, Freifelder R, Adzick NS, Alavi A, Stanley CA

Author

Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Confidence Intervals
Congenital Hyperinsulinism
Dihydroxyphenylalanine
Female
Humans
Infant
Infant, Newborn
Injections, Intravenous
Male
Pancreas
Positron-Emission Tomography
Prospective Studies
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a