Faculty Collaboration Database

The frequency of HLA-B(∗)57:01 and the risk of abacavir hypersensitivity reactions in the majority population of Costa Rica. Hum Immunol 2014 Nov;75(11):1092-6

Date

10/07/2014

Pubmed ID

25286002

DOI

10.1016/j.humimm.2014.09.011

Scopus ID

2-s2.0-84908491530 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

HLA-B(∗)57:01 is a well-known and cost-effective pharmacogenetic marker for abacavir hypersensitivity. As with other HLA alleles, there is widespread variation in its frequency across populations. The Costa Rica Central Valley Population (CCVP) is the major population in this country. The frequency of HLA-B(∗)57:01 in this population has not been described yet. Thus, our aim was to determine the frequency of this allele in the CCVP. 200 unrelated healthy volunteer donors born in the CCVP were typed. HLA-B(∗)57-positive samples identified by HLA intermediate resolution typing methods were further typed by SBT to high resolution. An HLA-B(∗)57:01 carrier frequency of 5.00% was determined in this sample. This frequency is relatively high in comparison to reports from other populations in Latin America. These results suggest that there is a considerable frequency of HLA-B(∗)57:01 in the CCVP and that pharmacogenetic testing for HIV+ patients who are going to receive abacavir-based treatment should be considered in this country.

Author List

Arrieta-Bolaños E, Madrigal JA, Marsh SG, Shaw BE, Salazar-Sánchez L

Author

Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Alleles
Anti-HIV Agents
Costa Rica
Dideoxynucleosides
Drug Hypersensitivity
Female
Gene Expression
Gene Frequency
Genetic Markers
HIV Infections
HLA-B Antigens
Heterozygote
Humans
Male
Risk Factors