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A residue-free green synergistic antifungal nanotechnology for pesticide thiram by ZnO nanoparticles. Sci Rep 2014 Jul 14;4:5408



Pubmed ID


Pubmed Central ID




Scopus ID

2-s2.0-84904489358   33 Citations


Here we reported a residue-free green nanotechnology which synergistically enhance the pesticides efficiency and successively eliminate its residue. We built up a composite antifungal system by a simple pre-treating and assembling procedure for investigating synergy. Investigations showed 0.25 g/L ZnO nanoparticles (NPs) with 0.01 g/L thiram could inhibit the fungal growth in a synergistic mode. More importantly, the 0.25 g/L ZnO NPs completely degraded 0.01 g/L thiram under simulated sunlight irradiation within 6 hours. It was demonstrated that the formation of ZnO-thiram antifungal system, electrostatic adsorption of ZnO NPs to fungi cells and the cellular internalization of ZnO-thiram composites played important roles in synergy. Oxidative stress test indicated ZnO-induced oxidative damage was enhanced by thiram that finally result in synergistic antifungal effect. By reducing the pesticides usage, this nanotechnology could control the plant disease economically, more significantly, the following photocatalytic degradation of pesticide greatly benefit the human social by avoiding negative influence of pesticide residue on public health and environment.

Author List

Xue J, Luo Z, Li P, Ding Y, Cui Y, Wu Q


Jake Luo Ph.D. Associate Professor; Director, Center for Biomedical Data and Language Processing (BioDLP) in the Health Informatics & Administration department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Drug Stability
Drug Synergism
Fungicides, Industrial
Green Chemistry Technology
Microbial Sensitivity Tests
Plant Diseases
Zinc Oxide