Life-threatening bleeding in a patient with mild hemophilia A and heterozygosity for von Willebrand disease Type 2N. Int J Hematol 2014 Dec;100(6):602-6
Date
09/13/2014Pubmed ID
25212677DOI
10.1007/s12185-014-1662-3Scopus ID
2-s2.0-84916641400 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Hemophilia A and von Willebrand disease (VWD) are distinct bleeding disorders with a spectrum of clinical phenotypes. They are characterized by mutations in either factor VIII (F8) or von Willebrand factor (VWF) genes, respectively. The pattern of inheritance and appropriate laboratory evaluation differentiates these diseases, and treatment strategies for both are different. Here, we report a male patient with hemophilia A and VWD Type 2 Normandy (N) mutations who presented with life-threatening bleeding. We document his medical history, clinical course, management, and diagnostic work up.
Author List
Allan JN, Friedman KD, DeSancho MTAuthor
Kenneth D. Friedman MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Biopsy, NeedleDeamino Arginine Vasopressin
Factor VIII
Hemophilia A
Hemorrhage
Heterozygote
Humans
Male
Middle Aged
Postoperative Hemorrhage
Shock, Hemorrhagic
Treatment Outcome
von Willebrand Disease, Type 2
