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Intention tremor and deficits of sensory feedback control in multiple sclerosis: a pilot study. J Neuroeng Rehabil 2014 Dec 19;11:170

Date

12/21/2014

Pubmed ID

25526770

Pubmed Central ID

PMC4292988

DOI

10.1186/1743-0003-11-170

Scopus ID

2-s2.0-84961751366   8 Citations

Abstract

BACKGROUND: Intention tremor and dysmetria are leading causes of upper extremity disability in Multiple Sclerosis (MS). The development of effective therapies to reduce tremor and dysmetria is hampered by insufficient understanding of how the distributed, multi-focal lesions associated with MS impact sensorimotor control in the brain. Here we describe a systems-level approach to characterizing sensorimotor control and use this approach to examine how sensory and motor processes are differentially impacted by MS.

METHODS: Eight subjects with MS and eight age- and gender-matched healthy control subjects performed visually-guided flexion/extension tasks about the elbow to characterize a sensory feedback control model that includes three sensory feedback pathways (one for vision, another for proprioception and a third providing an internal prediction of the sensory consequences of action). The model allows us to characterize impairments in sensory feedback control that contributed to each MS subject's tremor.

RESULTS: Models derived from MS subject performance differed from those obtained for control subjects in two ways. First, subjects with MS exhibited markedly increased visual feedback delays, which were uncompensated by internal adaptive mechanisms; stabilization performance in individuals with the longest delays differed most from control subject performance. Second, subjects with MS exhibited misestimates of arm dynamics in a way that was correlated with tremor power. Subject-specific models accurately predicted kinematic performance in a reach and hold task for neurologically-intact control subjects while simulated performance of MS patients had shorter movement intervals and larger endpoint errors than actual subject responses. This difference between simulated and actual performance is consistent with a strategic compensatory trade-off of movement speed for endpoint accuracy.

CONCLUSIONS: Our results suggest that tremor and dysmetria may be caused by limitations in the brain's ability to adapt sensory feedback mechanisms to compensate for increases in visual information processing time, as well as by errors in compensatory adaptations of internal estimates of arm dynamics.

Author List

Heenan M, Scheidt RA, Woo D, Beardsley SA

Authors

Scott Beardsley PhD Associate Professor in the Biomedical Engineering department at Marquette University
Robert Scheidt BS,MS,PhD Associate Professor in the Biomedical Engineering department at Marquette University




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Brain
Feedback, Sensory
Female
Humans
Male
Middle Aged
Models, Biological
Movement
Multiple Sclerosis
Pilot Projects
Proprioception
Tremor
Young Adult