Faculty Collaboration Database

Discovery of Cushing's Syndrome After Bariatric Surgery: Multicenter Series of 16 Patients. Obes Surg 2015 Dec;25(12):2306-13

Date

04/29/2015

Pubmed ID

25917980

DOI

10.1007/s11695-015-1681-z

Scopus ID

2-s2.0-84947494292 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

PURPOSE: The aim of this study is to demonstrate the importance of considering Cushing's syndrome (CS) as a potential etiology for weight gain and metabolic complications in patients undergoing bariatric surgery (BS).

DESIGN AND METHODS: This is a retrospective chart review case series of patients (n = 16) with CS from five tertiary care centers in the USA who had BS.

RESULTS: Median age at BS surgery was 35.5 years (median 2.5 years between BS and CS surgery). CS was not identified in 12 patients prior to BS. Four patients had CS surgery prior to BS, without recognition of recurrent or persistent CS until after BS. Median body mass index (BMI) values before BS, nadir after BS, prior to surgery for CS, and after surgery for CS were 47, 31, 38, and 35 kg/m(2), respectively. Prior to BS, 55 % of patients had hypertension and 55 % had diabetes mellitus. Only 17 % had resolution of hypertension or diabetes mellitus after BS.

CONCLUSION: CS may be under-recognized in patients undergoing BS. Testing for CS should be performed prior to BS in patients with features of CS and in post-operative BS patients with persistent hypertension, diabetes mellitus, or excessive weight regain. Studies should be conducted to determine the role of prospective testing for CS in subjects considering BS.

Author List

Javorsky BR, Carroll TB, Tritos NA, Salvatori R, Heaney AP, Fleseriu M, Biller BM, Findling JW

Authors

Ty Carroll MD Associate Professor in the Medicine department at Medical College of Wisconsin
James W. Findling MD Professor in the Medicine department at Medical College of Wisconsin
Bradley R. Javorsky MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Bariatric Surgery
Body Mass Index
Cushing Syndrome
Female
Humans
Hypertension
Male
Middle Aged
Obesity, Morbid
Postoperative Period
Retrospective Studies
Treatment Failure
Weight Gain
Young Adult