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Disabling the platelet's brakes to promote thrombosis. Blood 2015 Apr 23;125(17):2591-3

Date

04/25/2015

Pubmed ID

25907902

DOI

10.1182/blood-2015-03-630822

Scopus ID

2-s2.0-84928317219 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

In this issue of Blood, Magwenzi et al from the University of Hull report a novel mechanistic connection between oxidized low-density lipoprotein (oxLDL)-induced prothrombotic platelet signaling and the inhibition of endogenous platelet anti-activating signaling mediated by the nitric oxide (NO)/guanosine 3′,5′-cyclic monophosphate (cGMP)/protein kinase G (PKG) pathway.

Author List

Silverstein RL

Author

Roy L. Silverstein MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Platelets
CD36 Antigens
Cyclic GMP-Dependent Protein Kinases
Humans
Lipoproteins, LDL
Membrane Glycoproteins
NADPH Oxidases
Signal Transduction