Respiratory responses to aortic and carotid chemoreceptor activation in the dog. J Appl Physiol (1985) 1991 Jun;70(6):2539-50
Date
06/01/1991Pubmed ID
1885448DOI
10.1152/jappl.1991.70.6.2539Scopus ID
2-s2.0-0025796589 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Respiratory responses arising from both chemical stimulation of vascularly isolated aortic body (AB) and carotid body (CB) chemoreceptors and electrical stimulation of aortic nerve (AN) and carotid sinus nerve (CSN) afferents were compared in the anesthetized dog. Respiratory reflexes were measured as changes in inspiratory duration (TI), expiratory duration (TE), and peak averaged phrenic nerve activity (PPNG). Tonic AN and AB stimulations shortened TI and TE with no change in PPNG, while tonic CSN and CB stimulations shortened TE, increased PPNG, and transiently lengthened TI. Phasic AB and AN stimulations throughout inspiration shortened TI with no changes in PPNG or the following TE; however, similar phasic stimulations of the CB and CSN increased both TI and PPNG and decreased the following TE. Phasic AN stimulation during expiration decreased TE and the following TI with no change in PPNG. Similar stimulations of the CB and CSN decreased TE; however, the following TI and PPNG were increased. These findings differ from those found in the cat and suggest that aortic chemoreceptors affect mainly phase timing, while carotid chemoreceptors affect both timing and respiratory drive.
Author List
Hopp FA, Seagard JL, Bajić J, Zuperku EJAuthors
Jurica Bajic MD, PhD Assistant Professor in the Anesthesiology department at Medical College of WisconsinEdward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Afferent PathwaysAnimals
Aortic Bodies
Blood Pressure
Carotid Body
Carotid Sinus
Chemoreceptor Cells
Dogs
Electric Stimulation
Female
Male
Phrenic Nerve
Respiratory Mechanics
Stimulation, Chemical
