Faculty Collaboration Database

Peptides in seminal fluid and their role in infertility: a potential role for opiorphin inhibition of neutral endopeptidase activity as a clinically relevant modulator of sperm motility: a review. Reprod Sci 2014 Nov;21(11):1334-40

Date

05/24/2014

Pubmed ID

24855109

Pubmed Central ID

PMC4212334

DOI

10.1177/1933719114536473

Scopus ID

2-s2.0-84909630913 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

Infertility is a devastating medical condition that adversely affects emotional health and well-being of couples who desire pregnancy and parenthood. The overall demographic data suggest that the indication for more than one-third of assisted reproductive technology cycles performed in the United States includes male factor infertility. There is increasing recognition of the role that peptides present in seminal plasma have in determining sperm motility. Several recent studies suggest that peptidases, such as neutral endopeptidase (NEP) and aminopeptidase N (APN), impose significant adverse effects on sperm motility. Interestingly, several recent studies demonstrate that there is an endogenous NEP/APN inhibitor peptide called opiorphin in human seminal plasma. Our pilot studies suggest opiorphin promotes sperm motility and may positively influence sperm motility parameters in some cases of males infertility characterized by asthenozoospermia.

Author List

Bosler JS, Davies KP, Neal-Perry GS

Author

Jayme S. Bosler MD Associate Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Fertility
Humans
Infertility, Male
Male
Neprilysin
Oligopeptides
Proteinase Inhibitory Proteins, Secretory
Salivary Proteins and Peptides
Semen
Seminal Plasma Proteins
Signal Transduction
Sperm Motility
Spermatozoa