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Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus. AIDS 2005 Sep 23;19(14):1543-6

Date

09/02/2005

Pubmed ID

16135910

DOI

10.1097/01.aids.0000183521.90878.79

Scopus ID

2-s2.0-25844482999 (requires institutional sign-in at Scopus site)   31 Citations

Abstract

A lack of viral replication after HIV-1Ba-L (R5) but not HIV-1IIIB (X4) infection was found using in-vitro activated peripheral blood-derived mononuclear cells from patients with Fabry disease, who have a defect in the catabolism of globotriaosylceramide. CCR5, but not CD4 or CXCR4 expression levels, were lower and the surface expression of globotriaosylceramide was negligible on activated patients' cells. Our findings suggest a novel resistance mechanism to productive infection with R5 HIV-1 that potentially involves abnormal globotriaosylceramide catabolism.

Author List

Lund N, Branch DR, Sakac D, Lingwood CA, Siatskas C, Robinson CJ, Brady RO, Medin JA

Author

Jeffrey A. Medin PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

CD4 Antigens
Case-Control Studies
Fabry Disease
HIV Infections
HIV-1
Humans
Leukocytes, Mononuclear
Lymphocyte Activation
Receptors, CCR5
Receptors, CXCR4
Trihexosylceramides
Virus Replication