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Jeffrey A. Medin PhD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology and Oncology - Pediatrics
Program: Oncology

Member of the Cancer Center
Member of the Center for Immunology

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Publications (181)

Adiponectin overexpression improves metabolic abnormalities caused by acid ceramidase deficiency but does not prolong lifespan in a mouse model of Farber Disease. (Norris MK, Tippetts TS, Wilkerson JL, Nicholson RJ, Maschek JA, Levade T, Medin JA, Summers SA, Holland WL) Mol Genet Metab Rep 2024 Jun;39:101077 PMID: 38595987 PMCID: PMC11002753 SCOPUS ID: 2-s2.0-85189653604 04/10/2024

Molecular therapeutics in hematology: Gene therapy (McKillop WM, Medin JA) Molecular Hematology 8 March 2024:321-341 SCOPUS ID: 2-s2.0-85190229226 03/08/2024

Novel anti-CD30/CD3 bispecific antibodies activate human T cells and mediate potent anti-tumor activity. (Faber ML, Oldham RAA, Thakur A, Rademacher MJ, Kubicka E, Dlugi TA, Gifford SA, McKillop WM, Schloemer NJ, Lum LG, Medin JA) Front Immunol 2023;14:1225610 PMID: 37646042 PMCID: PMC10461807 SCOPUS ID: 2-s2.0-85168950041 08/30/2023 1 Citation

A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice. (Wang X, McKillop WM, Dlugi TA, Faber ML, Alvarez-Argote J, Chambers CB, Wilber A, Medin JA) J Gene Med 2024 Jan;26(1):e3567 PMID: 37455676 SCOPUS ID: 2-s2.0-85165380220 07/17/2023

Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency. (Nagree MS, Rybova J, Kleynerman A, Ahrenhoerster CJ, Saville JT, Xu T, Bachochin M, McKillop WM, Lawlor MW, Pshezhetsky AV, Isaeva O, Budde MD, Fuller M, Medin JA) Commun Biol 2023 May 25;6(1):560 PMID: 37231125 PMCID: PMC10212955 SCOPUS ID: 2-s2.0-85160222255 05/26/2023 2 Citations

Corrigendum to "Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing" [2021 Sep-Oct;134(1-2):117-131]. (Domm JM, Wootton SK, Medin JA, West ML) Mol Genet Metab 2023 May;139(1):107541 PMID: 36849293 SCOPUS ID: 2-s2.0-85150442762 02/28/2023

Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions. (Kleynerman A, Rybova J, Faber ML, McKillop WM, Levade T, Medin JA) Biomolecules 2023 Feb 01;13(2) PMID: 36830643 PMCID: PMC9953133 SCOPUS ID: 2-s2.0-85148964076 02/26/2023 2 Citations

Persistent hematopoietic polyclonality after lentivirus-mediated gene therapy for Fabry disease. (Saleh AH, Rothe M, Barber DL, McKillop WM, Fraser G, Morel CF, Schambach A, Auray-Blais C, West ML, Khan A, Fowler DH, Rupar CA, Foley R, Medin JA, Keating A) Mol Ther Methods Clin Dev 2023 Mar 09;28:262-271 PMID: 36816757 PMCID: PMC9932294 SCOPUS ID: 2-s2.0-85149784784 02/24/2023 2 Citations

Pathophysiological characterization of the Townes mouse model for sickle cell disease. (Alvarez-Argote J, Dlugi TA, Sundararajan T, Kleynerman A, Faber ML, McKillop WM, Medin JA) Transl Res 2023 Apr;254:77-91 PMID: 36323381 SCOPUS ID: 2-s2.0-85145313487 11/03/2022 4 Citations

Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency. (Rybova J, Kuchar L, Sikora J, McKillop WM, Medin JA) J Inherit Metab Dis 2022 Nov;45(6):1175-1190 PMID: 36083604 PMCID: PMC9826362 SCOPUS ID: 2-s2.0-85138302520 09/10/2022 3 Citations

rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis. (Zhang H, Nagree MS, Liu H, Pan X, Medin JA, Lipinski DM) Gene Ther 2023 Apr;30(3-4):297-308 PMID: 35902747 SCOPUS ID: 2-s2.0-85149011321 07/29/2022 2 Citations

Acid ceramidase deficiency: Farber lipogranulomatosis and spinal muscular atrophy with progressive myoclonic epilepsy (Levade T, Medin JA) Lysosomal Storage Disorders: A Practical Guide 22 July 2022:144-147 SCOPUS ID: 2-s2.0-85185623866 07/22/2022

Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes. (Rabionet M, Bernard P, Pichery M, Marsching C, Bayerle A, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Asadi A, Ebel P, Hoekstra M, Dumas S, Ntambi JM, Jacobsson A, Willecke K, Medin JA, Jonca N, Sandhoff R) Lipids 2022 May;57(3):183-195 PMID: 35318678 SCOPUS ID: 2-s2.0-85126876239 03/24/2022 3 Citations

Autologous, lentivirus-modified, T-rapa cell "micropharmacies" for lysosomal storage disorders. (Nagree MS, Felizardo TC, Faber ML, Rybova J, Rupar CA, Foley SR, Fuller M, Fowler DH, Medin JA) EMBO Mol Med 2022 Apr 07;14(4):e14297 PMID: 35298086 PMCID: PMC8988206 SCOPUS ID: 2-s2.0-85126359673 03/18/2022 3 Citations

Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing. (Domm JM, Wootton SK, Medin JA, West ML) Mol Genet Metab 2021;134(1-2):117-131 PMID: 34340879 SCOPUS ID: 2-s2.0-85111616049 08/04/2021 16 Citations

Sarcoma IL-12 overexpression facilitates NK cell immunomodulation. (Rademacher MJ, Cruz A, Faber M, Oldham RAA, Wang D, Medin JA, Schloemer NJ) Sci Rep 2021 Apr 15;11(1):8321 PMID: 33859303 PMCID: PMC8050085 SCOPUS ID: 2-s2.0-85104332873 04/17/2021 9 Citations

Lentivirus-mediated gene therapy for Fabry disease. (Khan A, Barber DL, Huang J, Rupar CA, Rip JW, Auray-Blais C, Boutin M, O'Hoski P, Gargulak K, McKillop WM, Fraser G, Wasim S, LeMoine K, Jelinski S, Chaudhry A, Prokopishyn N, Morel CF, Couban S, Duggan PR, Fowler DH, Keating A, West ML, Foley R, Medin JA) Nat Commun 2021 Feb 25;12(1):1178 PMID: 33633114 PMCID: PMC7907075 SCOPUS ID: 2-s2.0-85101751131 02/27/2021 60 Citations

Targeting oncoproteins with a positive selection assay for protein degraders. (Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG Jr) Sci Adv 2021 Feb;7(6) PMID: 33547076 PMCID: PMC7864573 SCOPUS ID: 2-s2.0-85100993075 02/07/2021 22 Citations

Discovery and validation of surface N-glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets. (Oldham RAA, Faber ML, Keppel TR, Buchberger AR, Waas M, Hari P, Gundry RL, Medin JA) J Immunother Cancer 2020 Aug;8(2) PMID: 32771993 PMCID: PMC7418848 SCOPUS ID: 2-s2.0-85089262124 08/11/2020 11 Citations

Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner. (Bayerle A, Marsching C, Rabionet M, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Herzer S, Jennemann R, Levade T, Medin JA, Sandhoff R) Biochim Biophys Acta Mol Cell Biol Lipids 2020 Sep;1865(9):158741 PMID: 32474112 SCOPUS ID: 2-s2.0-85085608737 06/01/2020 7 Citations

Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model. (Berger A, Colpitts SJ, Seabrook MSS, Furlonger CL, Bendix MB, Moreau JM, McKillop WM, Medin JA, Paige CJ) J Immunother Cancer 2019 Dec 19;7(1):355 PMID: 31856922 PMCID: PMC6924073 SCOPUS ID: 2-s2.0-85077039263 12/21/2019 15 Citations

Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target. (Li Y, Xu Y, Benitez BA, Nagree MS, Dearborn JT, Jiang X, Guzman MA, Woloszynek JC, Giaramita A, Yip BK, Elsbernd J, Babcock MC, Lo M, Fowler SC, Wozniak DF, Vogler CA, Medin JA, Crawford BE, Sands MS) Proc Natl Acad Sci U S A 2019 Oct 01;116(40):20097-20103 PMID: 31527255 PMCID: PMC6778236 SCOPUS ID: 2-s2.0-85072762154 09/19/2019 66 Citations

Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency. (Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA) Lab Invest 2019 Oct;99(10):1572-1592 PMID: 31186526 SCOPUS ID: 2-s2.0-85067402206 06/13/2019 11 Citations

Inherited monogenic defects of ceramide metabolism: Molecular bases and diagnoses. (Dubot P, Sabourdy F, Rybova J, Medin JA, Levade T) Clin Chim Acta 2019 Aug;495:457-466 PMID: 31128082 SCOPUS ID: 2-s2.0-85066236001 05/28/2019 1 Citation

An update on gene therapy for lysosomal storage disorders. (Nagree MS, Scalia S, McKillop WM, Medin JA) Expert Opin Biol Ther 2019 Jul;19(7):655-670 PMID: 31056978 SCOPUS ID: 2-s2.0-85068638885 05/07/2019 36 Citations

Lentiviral interleukin-10 gene therapy: Safety and questions. (Liu M, Juvet SC, Medin JA, Martinu T, Oishi H, Keshavjee S) J Thorac Cardiovasc Surg 2019 Feb;157(2):818-819 PMID: 30669243 SCOPUS ID: 2-s2.0-85060093792 01/24/2019 1 Citation

Molecular therapeutics in hematology: Gene therapy (McKillop WM, Medin JA) Molecular Hematology 1 January 2019:319-338 SCOPUS ID: 2-s2.0-85101891632 01/01/2019

Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells. (Neschadim A, Medin JA) Methods Mol Biol 2019;1895:149-163 PMID: 30539536 SCOPUS ID: 2-s2.0-85058602227 12/13/2018

Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury. (Islam D, Huang Y, Fanelli V, Delsedime L, Wu S, Khang J, Han B, Grassi A, Li M, Xu Y, Luo A, Wu J, Liu X, McKillop M, Medin J, Qiu H, Zhong N, Liu M, Laffey J, Li Y, Zhang H) Am J Respir Crit Care Med 2019 May 15;199(10):1214-1224 PMID: 30521764 SCOPUS ID: 2-s2.0-85065789775 12/07/2018 91 Citations

Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment. (Yu FPS, Sajdak BS, Sikora J, Salmon AE, Nagree MS, Gurka J, Kassem IS, Lipinski DM, Carroll J, Medin JA) Am J Pathol 2019 Feb;189(2):320-338 PMID: 30472209 PMCID: PMC6412726 SCOPUS ID: 2-s2.0-85060099082 11/26/2018 16 Citations

Human mesenchymal stromal cells do not promote recurrence of soft tissue sarcomas in mouse xenografts after radiation and surgery. (Filomeno PA, Kim KP, Yoon N, Rashedi I, Dayan V, Kandel RA, Wang XH, Felizardo TC, Berinstein E, Jelveh S, Filomeno A, Medin JA, Ferguson PC, Keating A) Cytotherapy 2018 Aug;20(8):1001-1012 PMID: 30076069 SCOPUS ID: 2-s2.0-85050668188 08/05/2018 1 Citation

Acid ceramidase deficiency: Farber disease and SMA-PME. (Yu FPS, Amintas S, Levade T, Medin JA) Orphanet J Rare Dis 2018 Jul 20;13(1):121 PMID: 30029679 PMCID: PMC6053731 SCOPUS ID: 2-s2.0-85050298830 07/22/2018 84 Citations

A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice. (Oishi H, Juvet SC, Martinu T, Sato M, Medin JA, Liu M, Keshavjee S) J Thorac Cardiovasc Surg 2018 Sep;156(3):1305-1315 PMID: 29937159 SCOPUS ID: 2-s2.0-85048714401 06/26/2018 20 Citations

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice. (Fougerat A, Pan X, Smutova V, Heveker N, Cairo CW, Issad T, Larrivée B, Medin JA, Pshezhetsky AV) Mol Metab 2018 Jun;12:76-88 PMID: 29735266 PMCID: PMC6001920 SCOPUS ID: 2-s2.0-85046664103 05/08/2018 46 Citations

Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency. (Yu FPS, Dworski S, Medin JA) Sci Rep 2018 Jan 29;8(1):1808 PMID: 29379059 PMCID: PMC5789088 SCOPUS ID: 2-s2.0-85041374187 01/31/2018 15 Citations

Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. (Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S) J Vis Exp 2018 Jan 15(131) PMID: 29364266 PMCID: PMC5908645 SCOPUS ID: 2-s2.0-85041082468 01/25/2018 11 Citations

Yin and Yang of mesenchymal stem cells and aplastic anemia. (Broglie L, Margolis D, Medin JA) World J Stem Cells 2017 Dec 26;9(12):219-226 PMID: 29321823 PMCID: PMC5746642 SCOPUS ID: 2-s2.0-85041751810 01/13/2018 11 Citations

Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency. (Yu FPS, Islam D, Sikora J, Dworski S, Gurka J, López-Vásquez L, Liu M, Kuebler WM, Levade T, Zhang H, Medin JA) Am J Physiol Lung Cell Mol Physiol 2018 Mar 01;314(3):L406-L420 PMID: 29167126 PMCID: PMC5900354 SCOPUS ID: 2-s2.0-85041372176 11/24/2017 25 Citations

Sphingolipid pathway enzymes modulate cell fate and immune responses. (Molino S, Tate E, McKillop WM, Medin JA) Immunotherapy 2017 Nov;9(14):1185-1198 PMID: 29067886 SCOPUS ID: 2-s2.0-85032440636 10/27/2017 22 Citations

Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. (Nomura R, Sato T, Sato Y, Medin JA, Kushimoto S, Yanagisawa T) Redox Biol 2017 Oct;13:407-417 PMID: 28683400 PMCID: PMC5498287 SCOPUS ID: 2-s2.0-85021668617 07/07/2017 13 Citations

Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34⁺ Cells for Correction of Fabry Disease. (Huang J, Khan A, Au BC, Barber DL, López-Vásquez L, Prokopishyn NL, Boutin M, Rothe M, Rip JW, Abaoui M, Nagree MS, Dworski S, Schambach A, Keating A, West ML, Klassen J, Turner PV, Sirrs S, Rupar CA, Auray-Blais C, Foley R, Medin JA) Mol Ther Methods Clin Dev 2017 Jun 16;5:241-258 PMID: 28603745 PMCID: PMC5453867 SCOPUS ID: 2-s2.0-85020540097 06/13/2017 35 Citations

Practical considerations for chimeric antigen receptor design and delivery. (Oldham RAA, Medin JA) Expert Opin Biol Ther 2017 Aug;17(8):961-978 PMID: 28586264 SCOPUS ID: 2-s2.0-85023630131 06/07/2017 14 Citations

Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. (Sikora J, Dworski S, Jones EE, Kamani MA, Micsenyi MC, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Dunn CK, Xuan ICY, Casas J, Fabrias G, Hampson DR, Levade T, Drake RR, Medin JA, Walkley SU) Am J Pathol 2017 Apr;187(4):864-883 PMID: 28342444 PMCID: PMC5397689 SCOPUS ID: 2-s2.0-85016006315 03/28/2017 38 Citations

Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice. (He X, Dworski S, Zhu C, DeAngelis V, Solyom A, Medin JA, Simonaro CM, Schuchman EH) BBA Clin 2017 Jun;7:85-96 PMID: 28275553 PMCID: PMC5338723 SCOPUS ID: 2-s2.0-85014209961 03/10/2017 31 Citations

Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion. (Kamani MA, Provençal P, Boutin M, Pacienza N, Fan X, Novak A, Huang TC, Binnington B, Au BC, Auray-Blais C, Lingwood CA, Medin JA) Future Sci OA 2016 Dec;2(4):FSO147 PMID: 28116130 PMCID: PMC5242178 SCOPUS ID: 2-s2.0-85043631559 01/25/2017 5 Citations

Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML. (Huang J, Liu Y, Au BC, Barber DL, Arruda A, Schambach A, Rothe M, Minden MD, Paige CJ, Medin JA) Mol Ther Methods Clin Dev 2016;3:16074 PMID: 27933304 PMCID: PMC5142463 SCOPUS ID: 2-s2.0-85015148027 12/10/2016 17 Citations

Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy. (Dworski S, Lu P, Khan A, Maranda B, Mitchell JJ, Parini R, Di Rocco M, Hugle B, Yoshimitsu M, Magnusson B, Makay B, Arslan N, Guelbert N, Ehlert K, Jarisch A, Gardner-Medwin J, Dagher R, Terreri MT, Lorenco CM, Barillas-Arias L, Tanpaiboon P, Solyom A, Norris JS, He X, Schuchman EH, Levade T, Medin JA) Biochim Biophys Acta Mol Basis Dis 2017 Feb;1863(2):386-394 PMID: 27915031 PMCID: PMC7192210 SCOPUS ID: 2-s2.0-85001975441 12/05/2016 32 Citations

Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues. (Desnick RJ, Barton NW, Furbish S, Grabowski GA, Karlsson S, Kolodny EH, Medin JA, Murray GJ, Mistry PK, Patterson MC, Schiffmann R, Weinreb NJ) Mol Genet Metab 2017;120(1-2):1-7 PMID: 27866832 SCOPUS ID: 2-s2.0-85006830465 11/22/2016 2 Citations

Roscoe Owen Brady: Passion for patients. (Medin JA) Proc Natl Acad Sci U S A 2016 Oct 18;113(42):11644-11645 PMID: 27791045 PMCID: PMC5081591 SCOPUS ID: 2-s2.0-84991716522 10/30/2016

Development of Novel Immunotherapies for Multiple Myeloma. (Al-Hujaily EM, Oldham RA, Hari P, Medin JA) Int J Mol Sci 2016 Sep 08;17(9) PMID: 27618026 PMCID: PMC5037783 SCOPUS ID: 2-s2.0-84987722672 09/13/2016 21 Citations

Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry. (Provençal P, Boutin M, Dworski S, Au B, Medin JA, Auray-Blais C) Bioanalysis 2016 Sep;8(17):1793-807 PMID: 27523577 PMCID: PMC4992964 SCOPUS ID: 2-s2.0-84983661922 08/16/2016 14 Citations

Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns. (Resetca D, Neschadim A, Medin JA) J Immunother 2016 Sep;39(7):249-59 PMID: 27488725 SCOPUS ID: 2-s2.0-84980410213 08/05/2016 8 Citations

Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques. (Au BC, Lee CJ, Lopez-Perez O, Foltz W, Felizardo TC, Wang JCM, Huang J, Fan X, Madden M, Goldstein A, Jaffray DA, Moloo B, McCart JA, Medin JA) Biomedicines 2016 Feb 19;4(1) PMID: 28536373 PMCID: PMC5344243 SCOPUS ID: 2-s2.0-85054216681 02/19/2016 1 Citation

Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy. (Nagree MS, López-Vásquez L, Medin JA) World J Stem Cells 2015 Dec 26;7(11):1233-50 PMID: 26730268 PMCID: PMC4691692 01/06/2016

Detection and distribution of sphingolipids in tissue by FTICR MALDI-imaging mass spectrometry (Ellen Jones E, Dworski S, Kamani M, Canals D, Wada M, Liu X, Hannun YA, Norris J, Medin JA, Drake RR) Bioactive Sphingolipids in Cancer Biology and Therapy August 28, 2015:339-358 SCOPUS ID: 2-s2.0-84956520280 08/28/2015 2 Citations

Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis. (Sato T, Neschadim A, Nakagawa R, Yanagisawa T, Medin JA) Methods Mol Biol 2015;1317:55-67 PMID: 26072401 SCOPUS ID: 2-s2.0-84931265253 06/15/2015 3 Citations

Lentiviral vectors in cancer immunotherapy. (Oldham RA, Berinstein EM, Medin JA) Immunotherapy 2015;7(3):271-84 PMID: 25804479 SCOPUS ID: 2-s2.0-84925805603 03/26/2015 28 Citations

Markedly perturbed hematopoiesis in acid ceramidase deficient mice. (Dworski S, Berger A, Furlonger C, Moreau JM, Yoshimitsu M, Trentadue J, Au BC, Paige CJ, Medin JA) Haematologica 2015 May;100(5):e162-5 PMID: 25682603 PMCID: PMC4420221 SCOPUS ID: 2-s2.0-84929145824 02/16/2015 17 Citations

Advances in haplo-identical stem cell transplantation in adults with high-risk hematological malignancies. (Ricci MJ, Medin JA, Foley RS) World J Stem Cells 2014 Sep 26;6(4):380-90 PMID: 25258660 PMCID: PMC4172667 09/27/2014

Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity. (Nelles ME, Moreau JM, Furlonger CL, Berger A, Medin JA, Paige CJ) Cancer Immunol Res 2014 Nov;2(11):1113-24 PMID: 25154710 SCOPUS ID: 2-s2.0-84940100387 08/27/2014 11 Citations

On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. (Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR) Anal Chem 2014 Aug 19;86(16):8303-11 PMID: 25072097 PMCID: PMC4139181 SCOPUS ID: 2-s2.0-84906263611 07/30/2014 59 Citations

Localized interleukin-12 delivery for immunotherapy of solid tumours. (Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ) J Cell Mol Med 2013 Nov;17(11):1465-74 PMID: 24251770 PMCID: PMC4117559 SCOPUS ID: 2-s2.0-84891148986 11/21/2013 14 Citations

The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer. (Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA) PLoS One 2013;8(10):e78711 PMID: 24194950 PMCID: PMC3806853 SCOPUS ID: 2-s2.0-84886070529 11/07/2013 27 Citations

Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways. (Wang JC, Felizardo TC, Au BC, Fowler DH, Dekaban GA, Medin JA) Virol J 2013 Jul 20;10:240 PMID: 23870437 PMCID: PMC3723442 SCOPUS ID: 2-s2.0-84880334859 07/23/2013 9 Citations

Systemic ceramide accumulation leads to severe and varied pathological consequences. (Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA) EMBO Mol Med 2013 Jun;5(6):827-42 PMID: 23681708 PMCID: PMC3779446 SCOPUS ID: 2-s2.0-84878688969 05/18/2013 85 Citations

Harnessing autophagy for cell fate control gene therapy. (Felizardo TC, Foley J, Steed K, Dropulic B, Amarnath S, Medin JA, Fowler DH) Autophagy 2013 Jul;9(7):1069-79 PMID: 23633667 PMCID: PMC3722316 SCOPUS ID: 2-s2.0-84880885997 05/02/2013 8 Citations

Lentivirus IL-10 gene therapy down-regulates IL-17 and attenuates mouse orthotopic lung allograft rejection. (Hirayama S, Sato M, Loisel-Meyer S, Matsuda Y, Oishi H, Guan Z, Saito T, Yeung J, Cypel M, Hwang DM, Medin JA, Liu M, Keshavjee S) Am J Transplant 2013 Jun;13(6):1586-93 PMID: 23601206 SCOPUS ID: 2-s2.0-84878503027 04/23/2013 40 Citations

Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity. (Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC) Brain Behav Immun 2013 May;30:103-14 PMID: 23369732 SCOPUS ID: 2-s2.0-84876838564 02/02/2013 49 Citations

Brief report: The potential role of epigenetics on multipotent cell differentiation capacity of mesenchymal stromal cells. (Yannarelli G, Pacienza N, Cuniberti L, Medin J, Davies J, Keating A) Stem Cells 2013 Jan;31(1):215-20 PMID: 23097343 SCOPUS ID: 2-s2.0-84871566166 10/26/2012 40 Citations

Human umbilical cord perivascular cells exhibit enhanced cardiomyocyte reprogramming and cardiac function after experimental acute myocardial infarction. (Yannarelli G, Dayan V, Pacienza N, Lee CJ, Medin J, Keating A) Cell Transplant 2013;22(9):1651-66 PMID: 23043977 SCOPUS ID: 2-s2.0-84883532879 10/10/2012 40 Citations

Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia. (Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA) Hum Gene Ther 2012 Dec;23(12):1280-9 PMID: 22998370 SCOPUS ID: 2-s2.0-84871257903 09/25/2012 4 Citations

Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. (Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T) Mol Cell Proteomics 2012 Dec;11(12):1870-84 PMID: 22986220 PMCID: PMC3518113 SCOPUS ID: 2-s2.0-84870679496 09/19/2012 75 Citations

Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice. (Pacienza N, Yoshimitsu M, Mizue N, Au BC, Wang JC, Fan X, Takenaka T, Medin JA) Mol Ther 2012 Jul;20(7):1454-61 PMID: 22472949 PMCID: PMC3393855 SCOPUS ID: 2-s2.0-84863430009 04/05/2012 24 Citations

Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer. (Neschadim A, Wang JC, Lavie A, Medin JA) Cancer Gene Ther 2012 May;19(5):320-7 PMID: 22388453 SCOPUS ID: 2-s2.0-84862779108 03/06/2012 20 Citations

Identification of prostate-enriched proteins by in-depth proteomic analyses of expressed prostatic secretions in urine. (Principe S, Kim Y, Fontana S, Ignatchenko V, Nyalwidhe JO, Lance RS, Troyer DA, Alessandro R, Semmes OJ, Kislinger T, Drake RR, Medin JA) J Proteome Res 2012 Apr 06;11(4):2386-96 PMID: 22339264 PMCID: PMC3642074 SCOPUS ID: 2-s2.0-84859570127 02/22/2012 62 Citations

Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. (Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA) Mol Ther 2012 May;20(5):1002-13 PMID: 22273576 PMCID: PMC3345984 SCOPUS ID: 2-s2.0-84862829497 01/26/2012 19 Citations

Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model. (Swift BE, Williams BA, Kosaka Y, Wang XH, Medin JA, Viswanathan S, Martinez-Lopez J, Keating A) Haematologica 2012 Jul;97(7):1020-8 PMID: 22271890 PMCID: PMC3396673 SCOPUS ID: 2-s2.0-84863908333 01/25/2012 48 Citations

Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes. (Scaife M, Pacienza N, Au BC, Wang JC, Devine S, Scheid E, Lee CJ, Lopez-Perez O, Neschadim A, Fowler DH, Foley R, Medin JA) Gene Ther 2013 Jan;20(1):24-34 PMID: 22241175 SCOPUS ID: 2-s2.0-84871978590 01/14/2012 16 Citations

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. (Amarnath S, Mangus CW, Wang JC, Wei F, He A, Kapoor V, Foley JE, Massey PR, Felizardo TC, Riley JL, Levine BL, June CH, Medin JA, Fowler DH) Sci Transl Med 2011 Nov 30;3(111):111ra120 PMID: 22133721 PMCID: PMC3235958 SCOPUS ID: 2-s2.0-82655184651 12/03/2011 352 Citations

Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro. (Berthod F, Symes J, Tremblay N, Medin JA, Auger FA) J Cell Physiol 2012 May;227(5):2130-7 PMID: 21769871 SCOPUS ID: 2-s2.0-84856170502 07/20/2011 31 Citations

Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways. (Hirayama S, Sato M, Liu M, Loisel-Meyer S, Yeung JC, Wagnetz D, Cypel M, Zehong G, Medin JA, Keshavjee S) Hum Gene Ther 2011 Nov;22(11):1453-60 PMID: 21568692 SCOPUS ID: 2-s2.0-81855184513 05/17/2011 23 Citations

Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model. (Felizardo TC, Wang JC, McGray RA, Evelegh C, Spaner DE, Fowler DH, Bramson JL, Medin JA) Gene Ther 2011 Oct;18(10):986-95 PMID: 21490686 PMCID: PMC6948845 SCOPUS ID: 2-s2.0-80054088221 04/15/2011 11 Citations

A novel tissue-engineered approach to problems of the postpneumonectomy space. (Tsunooka N, Hirayama S, Medin JA, Liles WC, Keshavjee S, Waddell TK) Ann Thorac Surg 2011 Mar;91(3):880-6 PMID: 21353020 SCOPUS ID: 2-s2.0-79951985195 03/01/2011 5 Citations

Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: pitfalls of mutation analyses in patients with low α-galactosidase A activity. (Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T) J Cardiol 2011 May;57(3):345-53 PMID: 21333496 SCOPUS ID: 2-s2.0-79955000143 02/22/2011 13 Citations

Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells. (Siegers GM, Dhamko H, Wang XH, Mathieson AM, Kosaka Y, Felizardo TC, Medin JA, Tohda S, Schueler J, Fisch P, Keating A) Cytotherapy 2011 Jul;13(6):753-64 PMID: 21314241 SCOPUS ID: 2-s2.0-79959272887 02/15/2011 74 Citations

Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic Ph+ leukemia model. (Siegers GM, Felizardo TC, Mathieson AM, Kosaka Y, Wang XH, Medin JA, Keating A) PLoS One 2011 Feb 03;6(2):e16700 PMID: 21304898 PMCID: PMC3033392 SCOPUS ID: 2-s2.0-79751483980 02/10/2011 34 Citations

Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. (Walia JS, Neschadim A, Lopez-Perez O, Alayoubi A, Fan X, Carpentier S, Madden M, Lee CJ, Cheung F, Jaffray DA, Levade T, McCart JA, Medin JA) Hum Gene Ther 2011 Jun;22(6):679-87 PMID: 21280983 PMCID: PMC3155125 SCOPUS ID: 2-s2.0-79958209082 02/02/2011 30 Citations

Experimental and applied immunotherapy (Medin J, Fowler D) Experimental and Applied Immunotherapy 2011:1-442 SCOPUS ID: 2-s2.0-84919957426 01/01/2011 1 Citation

Radiation therapy and cancer treatment: From the basics to combination therapies that ignite immunity (Moretti A, Jaffray DA, Medin JA) Experimental and Applied Immunotherapy 2011:357-388 SCOPUS ID: 2-s2.0-84919970495 01/01/2011

Radiation therapy and cancer treatment: From the basics to combination therapies that ignite immunity Experimental and Applied Immunotherapy 2011:357-388 01/01/2011

Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production. (Wang AY, Crome SQ, Jenkins KM, Medin JA, Bramson JL, Levings MK) Cancer Immunol Immunother 2011 Mar;60(3):381-8 PMID: 21153637 PMCID: PMC11028621 SCOPUS ID: 2-s2.0-79953817679 12/15/2010 3 Citations

Mesenchymal stromal cells expressing ErbB-2/neu elicit protective antibreast tumor immunity in vivo, which is paradoxically suppressed by IFN-gamma and tumor necrosis factor-alpha priming. (Romieu-Mourez R, François M, Abate A, Boivin MN, Birman E, Bailey D, Bramson JL, Forner K, Young YK, Medin JA, Galipeau J) Cancer Res 2010 Oct 15;70(20):7742-7 PMID: 20924101 SCOPUS ID: 2-s2.0-78049297908 10/07/2010 16 Citations

Promoter-specific lentivectors for long-term, cardiac-directed therapy of Fabry disease. (Lee CJ, Fan X, Guo X, Medin JA) J Cardiol 2011 Jan;57(1):115-22 PMID: 20846825 SCOPUS ID: 2-s2.0-78650576176 09/18/2010 33 Citations

A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. (Likar Y, Zurita J, Dobrenkov K, Shenker L, Cai S, Neschadim A, Medin JA, Sadelain M, Hricak H, Ponomarev V) J Nucl Med 2010 Sep;51(9):1395-403 PMID: 20810757 PMCID: PMC4405132 SCOPUS ID: 2-s2.0-77957087452 09/03/2010 55 Citations

Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice. (Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenaka T, Medin JA) Mol Med 2010;16(5-6):216-21 PMID: 20454522 PMCID: PMC2864812 SCOPUS ID: 2-s2.0-77951963462 05/11/2010 12 Citations

Functional repair of human donor lungs by IL-10 gene therapy. (Cypel M, Liu M, Rubacha M, Yeung JC, Hirayama S, Anraku M, Sato M, Medin J, Davidson BL, de Perrot M, Waddell TK, Slutsky AS, Keshavjee S) Sci Transl Med 2009 Oct 28;1(4):4ra9 PMID: 20368171 SCOPUS ID: 2-s2.0-77952001279 04/07/2010 256 Citations

In-depth proteomic analyses of direct expressed prostatic secretions. (Drake RR, Elschenbroich S, Lopez-Perez O, Kim Y, Ignatchenko V, Ignatchenko A, Nyalwidhe JO, Basu G, Wilkins CE, Gjurich B, Lance RS, Semmes OJ, Medin JA, Kislinger T) J Proteome Res 2010 May 07;9(5):2109-16 PMID: 20334419 PMCID: PMC2869496 SCOPUS ID: 2-s2.0-77952060884 03/26/2010 62 Citations

Molecular Therapeutics in Hematology: Gene Therapy (Medin JA) Molecular Hematology: Third Edition 10 March 2010:318-335 SCOPUS ID: 2-s2.0-84885815085 03/10/2010

Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction. (Fan X, Lang H, Zhou X, Zhang L, Yin R, Maciejko J, Giannitsos V, Motyka B, Medin JA, Platt JL, West LJ) Hum Gene Ther 2010 Jul;21(7):877-90 PMID: 20163247 PMCID: PMC2938359 SCOPUS ID: 2-s2.0-77957964184 02/19/2010 12 Citations

Sequencing and characterization of the porcine α-galactosidase A gene: towards the generation of a porcine model for Fabry disease. (Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T) Mol Biol Rep 2011 Jun;38(5):3145-52 PMID: 20131008 SCOPUS ID: 2-s2.0-80052457781 02/05/2010 4 Citations

Isolation of cell surface proteins for mass spectrometry-based proteomics. (Elschenbroich S, Kim Y, Medin JA, Kislinger T) Expert Rev Proteomics 2010 Feb;7(1):141-54 PMID: 20121483 SCOPUS ID: 2-s2.0-77951637328 02/04/2010 83 Citations

Comparative impact of trastuzumab and cyclophosphamide on HER-2-positive human breast cancer xenografts. (Francia G, Man S, Lee CJ, Lee CR, Xu P, Mossoba ME, Emmenegger U, Medin JA, Kerbel RS) Clin Cancer Res 2009 Oct 15;15(20):6358-66 PMID: 19825954 PMCID: PMC2788792 SCOPUS ID: 2-s2.0-70350243067 10/15/2009 36 Citations

Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection. (Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA) J Cardiol 2009 Oct;54(2):245-54 PMID: 19782262 SCOPUS ID: 2-s2.0-70349244738 09/29/2009 6 Citations

Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. (Silvertown JD, Neschadim A, Liu HN, Shannon P, Walia JS, Kao JC, Robertson J, Summerlee AJ, Medin JA) Regul Pept 2010 Jan 08;159(1-3):44-53 PMID: 19778557 SCOPUS ID: 2-s2.0-71349084185 09/26/2009 24 Citations

Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells. (Maekawa Y, Mizue N, Chan A, Shi Y, Liu Y, Dawood S, Chen M, Dawood F, de Couto G, Li GH, Suzuki N, Yeh WC, Gramolini A, Medin JA, Liu PP) Circulation 2009 Oct 06;120(14):1401-14 PMID: 19770394 SCOPUS ID: 2-s2.0-70349750287 09/23/2009 66 Citations

Novel application of lentiviral vectors towards treatment of graft-versus-host disease. (Scaife MD, Neschadim A, Fowler DH, Medin JA) Expert Opin Biol Ther 2009 Jun;9(6):749-61 PMID: 19456209 SCOPUS ID: 2-s2.0-67649120068 05/22/2009 6 Citations

Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection. (Loisel-Meyer S, Felizardo T, Mariotti J, Mossoba ME, Foley JE, Kammerer R, Mizue N, Keefe R, McCart JA, Zimmermann W, Dropulic B, Fowler DH, Medin JA) Mol Cancer Ther 2009 Mar;8(3):692-702 PMID: 19276164 PMCID: PMC2846382 SCOPUS ID: 2-s2.0-66449130673 03/12/2009 18 Citations

Multidimensional protein identification technology analysis highlights mitoxantrone-induced expression modulations in the primary prostate cancer cell proteome. (Symes J, Evangelou A, Ignatchenko A, Fleshner N, Kislinger T, Medin JA) Proteomics Clin Appl 2009 Mar;3(3):347-58 PMID: 26238752 SCOPUS ID: 2-s2.0-65549170553 03/01/2009

Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells. (Symes JC, Siatskas C, Fowler DH, Medin JA) Cancer Gene Ther 2009 May;16(5):439-52 PMID: 19096446 PMCID: PMC2857530 SCOPUS ID: 2-s2.0-65049090448 12/20/2008 7 Citations

Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction. (Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA) Mol Ther 2009 Feb;17(2):262-8 PMID: 19002160 PMCID: PMC2835055 SCOPUS ID: 2-s2.0-63649139251 11/13/2008 7 Citations

Long-term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-human choriogonadotropin secreting tumor cell lines. (Francia G, Emmenegger U, Lee CR, Shaked Y, Folkins C, Mossoba M, Medin JA, Man S, Zhu Z, Witte L, Kerbel RS) Mol Cancer Ther 2008 Oct;7(10):3452-9 PMID: 18852148 SCOPUS ID: 2-s2.0-55749115253 10/15/2008 24 Citations

In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease. (Ramsubir S, Nonaka T, Girbés CB, Carpentier S, Levade T, Medin JA) Mol Genet Metab 2008 Nov;95(3):133-41 PMID: 18805722 PMCID: PMC2614354 SCOPUS ID: 2-s2.0-53949084652 09/23/2008 29 Citations

Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel. (Symes JC, Kurin M, Fleshner NE, Medin JA) Mol Cancer Ther 2008 Sep;7(9):3018-28 PMID: 18790782 SCOPUS ID: 2-s2.0-54049125364 09/16/2008 21 Citations

IL-10 secretion increases signal persistence of HEMA-MMA-microencapsulated luciferase-modified CHO fibroblasts in mice. (Surzyn M, Symes J, Medin JA, Sefton MV) Tissue Eng Part A 2009 Jan;15(1):127-36 PMID: 18710337 SCOPUS ID: 2-s2.0-58149265302 08/20/2008 10 Citations

Transduction and transplantation of spermatogonia into the testis of ram lambs through the extra-testicular rete. (Rodriguez-Sosa JR, Silvertown JD, Foster RA, Medin JA, Hahnel A) Reprod Domest Anim 2009 Aug;44(4):612-20 PMID: 18694428 SCOPUS ID: 2-s2.0-67849128991 08/13/2008 21 Citations

IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy. (Labbe A, Nelles M, Walia J, Jia L, Furlonger C, Nonaka T, Medin JA, Paige CJ) J Cell Mol Med 2009 Aug;13(8B):1962-1976 PMID: 18624776 PMCID: PMC6512371 SCOPUS ID: 2-s2.0-72949086895 07/16/2008 18 Citations

Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials. (Loisel-Meyer S, Foley R, Medin JA) Front Biosci 2008 May 01;13:3202-14 PMID: 18508428 SCOPUS ID: 2-s2.0-42649109659 05/30/2008 20 Citations

Implementation of high-throughput screening for Fabry disease in Toronto dialysis patients. (Rasaiah VI, Underwood JP, Oreopoulos DG, Medin JA) NDT Plus 2008 Apr;1(2):129-130 PMID: 28657021 PMCID: PMC5477914 SCOPUS ID: 2-s2.0-41749100183 04/01/2008 9 Citations

Tumor protection following vaccination with low doses of lentivirally transduced DCs expressing the self-antigen erbB2. (Mossoba ME, Walia JS, Rasaiah VI, Buxhoeveden N, Head R, Ying C, Foley JE, Bramson JL, Fowler DH, Medin JA) Mol Ther 2008 Mar;16(3):607-17 PMID: 18180774 SCOPUS ID: 2-s2.0-39849098133 01/09/2008 22 Citations

A roadmap to safe, efficient, and stable lentivirus-mediated gene therapy with hematopoietic cell transplantation. (Neschadim A, McCart JA, Keating A, Medin JA) Biol Blood Marrow Transplant 2007 Dec;13(12):1407-16 PMID: 18022569 SCOPUS ID: 2-s2.0-36049014397 11/21/2007 34 Citations

Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling. (Formigli L, Perna AM, Meacci E, Cinci L, Margheri M, Nistri S, Tani A, Silvertown J, Orlandini G, Porciani C, Zecchi-Orlandini S, Medin J, Bani D) J Cell Mol Med 2007;11(5):1087-100 PMID: 17979884 PMCID: PMC4401276 SCOPUS ID: 2-s2.0-35649009903 11/06/2007 85 Citations

Local radiotherapy induces homing of hematopoietic stem cells to the irradiated bone marrow. (Bastianutto C, Mian A, Symes J, Mocanu J, Alajez N, Sleep G, Shi W, Keating A, Crump M, Gospodarowicz M, Medin J, Minden M, Liu FF) Cancer Res 2007 Nov 01;67(21):10112-6 PMID: 17974951 SCOPUS ID: 2-s2.0-35948974710 11/03/2007 29 Citations

Lentivirally Transduced Recipient-derived Dendritic Cells Serve to Ex Vivo Expand Functional FcRγ-sufficient Double-negative Regulatory T Cells. (Thomson CW, Mossoba ME, Siatskas C, Chen W, Sung A, Medin JA, Zhang L) Mol Ther 2007 Apr;15(4):818-824 PMID: 28192704 SCOPUS ID: 2-s2.0-33947264163 04/01/2007 3 Citations

Anti-CD25 targeted killing of bicistronically transduced cells: a novel safety mechanism against retroviral genotoxicity. (Ramsubir S, Yoshimitsu M, Medin JA) Mol Ther 2007 Jun;15(6):1174-81 PMID: 17387334 SCOPUS ID: 2-s2.0-34249300506 03/28/2007 8 Citations

Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. (Sato T, Neschadim A, Konrad M, Fowler DH, Lavie A, Medin JA) Mol Ther 2007 May;15(5):962-70 PMID: 17375075 SCOPUS ID: 2-s2.0-34247194881 03/22/2007 87 Citations

Lentiviral vectors for gene therapy of heart disease. (Higuchi K, Medin JA) J Cardiol 2007 Jan;49(1):1-11 PMID: 17269208 SCOPUS ID: 2-s2.0-33947539391 02/03/2007 3 Citations

Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells. (Thomson CW, Mossoba ME, Siatskas C, Chen W, Sung A, Medin JA, Zhang L) Mol Ther 2007 Apr;15(4):818-24 PMID: 17264854 SCOPUS ID: 2-s2.0-33947264163 02/01/2007 3 Citations

Multiple reduced-intensity conditioning regimens facilitate correction of Fabry mice after transplantation of transduced cells. (Liang SB, Yoshimitsu M, Poeppl A, Rasaiah VI, Cai J, Fowler DH, Medin JA) Mol Ther 2007 Mar;15(3):618-27 PMID: 17228315 SCOPUS ID: 2-s2.0-33847175575 01/18/2007 13 Citations

Analog of H2 relaxin exhibits antagonistic properties and impairs prostate tumor growth. (Silvertown JD, Symes JC, Neschadim A, Nonaka T, Kao JC, Summerlee AJ, Medin JA) FASEB J 2007 Mar;21(3):754-65 PMID: 17197386 SCOPUS ID: 2-s2.0-33847347702 01/02/2007 51 Citations

Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials. (Mossoba ME, Medin JA) Expert Rev Vaccines 2006 Oct;5(5):717-32 PMID: 17181444 SCOPUS ID: 2-s2.0-33845871185 12/22/2006 24 Citations

Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A. (Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA) Circ J 2006 Nov;70(11):1503-8 PMID: 17062978 SCOPUS ID: 2-s2.0-33750561515 10/26/2006 29 Citations

Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells. (Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka T, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA) Gene Ther 2007 Feb;14(3):256-65 PMID: 16929352 SCOPUS ID: 2-s2.0-33846544543 08/25/2006 45 Citations

Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1. Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model. (Mattocks M, Bagovich M, De Rosa M, Bond S, Binnington B, Rasaiah VI, Medin J, Lingwood C) FEBS J 2006 May;273(9):2064-75 PMID: 16724420 SCOPUS ID: 2-s2.0-33745260683 05/27/2006 21 Citations

Functional expression of mouse relaxin and mouse relaxin-3 in the lung from an Ebola virus glycoprotein-pseudotyped lentivirus via tracheal delivery. (Silvertown JD, Walia JS, Summerlee AJ, Medin JA) Endocrinology 2006 Aug;147(8):3797-808 PMID: 16709614 SCOPUS ID: 2-s2.0-33746053434 05/20/2006 24 Citations

Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. (Ayach BB, Yoshimitsu M, Dawood F, Sun M, Arab S, Chen M, Higuchi K, Siatskas C, Lee P, Lim H, Zhang J, Cukerman E, Stanford WL, Medin JA, Liu PP) Proc Natl Acad Sci U S A 2006 Feb 14;103(7):2304-9 PMID: 16467148 PMCID: PMC1413746 SCOPUS ID: 2-s2.0-33144455158 02/10/2006 105 Citations

Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts. (du Manoir JM, Francia G, Man S, Mossoba M, Medin JA, Viloria-Petit A, Hicklin DJ, Emmenegger U, Kerbel RS) Clin Cancer Res 2006 Feb 01;12(3 Pt 1):904-16 PMID: 16467105 SCOPUS ID: 2-s2.0-32944458087 02/10/2006 126 Citations

Effect of GFP expression on the sensitivity of glioma cell lines to photodynamic therapy (Khatami S, Rendon A, Yoshimitsu M, Medin J, Lilge L) Progress in Biomedical Optics and Imaging - Proceedings of SPIE 2005;5969 SCOPUS ID: 2-s2.0-33244482183 12/01/2005

Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus. (Lund N, Branch DR, Sakac D, Lingwood CA, Siatskas C, Robinson CJ, Brady RO, Medin JA) AIDS 2005 Sep 23;19(14):1543-6 PMID: 16135910 SCOPUS ID: 2-s2.0-25844482999 09/02/2005 31 Citations

Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms. (Siatskas C, Underwood J, Ramezani A, Hawley RG, Medin JA) FASEB J 2005 Oct;19(12):1752-4 PMID: 16076962 SCOPUS ID: 2-s2.0-26444514555 08/04/2005 10 Citations

H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. (Silvertown JD, Ng J, Sato T, Summerlee AJ, Medin JA) Int J Cancer 2006 Jan 01;118(1):62-73 PMID: 16049981 SCOPUS ID: 2-s2.0-27944447704 07/29/2005 74 Citations

Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA. (Silvertown JD, Walia JS, Medin JA) Dev Comp Immunol 2005;29(11):989-1002 PMID: 15935473 SCOPUS ID: 2-s2.0-21444440947 06/07/2005 2 Citations

Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo. (Medin JA, Liang SB, Hou JW, Kelley LS, Peace DJ, Fowler DH) Cancer Gene Ther 2005 Jun;12(6):540-51 PMID: 15678150 SCOPUS ID: 2-s2.0-18844416079 01/29/2005 24 Citations

Enhanced filter paper enzyme assay for high-throughput population screening for Fabry disease. (Poeppl AG, Murray GJ, Medin JA) Anal Biochem 2005 Feb 01;337(1):161-3 PMID: 15649390 SCOPUS ID: 2-s2.0-11844304402 01/15/2005 7 Citations

Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. (Yoshimitsu M, Sato T, Tao K, Walia JS, Rasaiah VI, Sleep GT, Murray GJ, Poeppl AG, Underwood J, West L, Brady RO, Medin JA) Proc Natl Acad Sci U S A 2004 Nov 30;101(48):16909-14 PMID: 15550536 PMCID: PMC534735 SCOPUS ID: 2-s2.0-10044223213 11/20/2004 79 Citations

Enhanced effect of vascular endothelial growth factor, thrombopoietin peptide agonist, SCF, and Flt3-L on LTC-IC and reporter gene transduction from umbilical cord blood CD34+ cells. (Smith SL, Kiss J, Siatskas C, Medin JA, Moldwin RL) Transfusion 2004 Mar;44(3):438-49 PMID: 14996204 SCOPUS ID: 2-s2.0-1642313669 03/05/2004 2 Citations

Efficacy of targeted FasL in nasopharyngeal carcinoma. (Li JH, Shi W, Chia M, Sanchez-Sweatman O, Siatskas C, Huang D, Busson P, Klamut H, Yeh WC, Richardson C, O'Sullivan B, Gullane P, Neligan P, Medin J, Liu FF) Mol Ther 2003 Dec;8(6):964-73 PMID: 14664799 SCOPUS ID: 2-s2.0-0346656768 12/11/2003 27 Citations

Vector divergence to convergence? (Medin JA) Gene Therapy August 2003;10(17):1407 SCOPUS ID: 2-s2.0-0042025176 08/01/2003

The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. (Veldman RJ, Mita A, Cuvillier O, Garcia V, Klappe K, Medin JA, Campbell JD, Carpentier S, Kok JW, Levade T) FASEB J 2003 Jun;17(9):1144-6 PMID: 12692077 SCOPUS ID: 2-s2.0-0038380478 04/15/2003 40 Citations

Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells: beyond efficiency issues. (Medin JA, Fowler DH) J Cell Biochem Suppl 2002;38:46-54 PMID: 12046849 SCOPUS ID: 2-s2.0-37649026220 06/06/2002 4 Citations

Gene therapy for Fabry disease. (Siatskas C, Medin JA) J Inherit Metab Dis 2001;24 Suppl 2:25-41; discussion 11-2 PMID: 11758676 SCOPUS ID: 2-s2.0-0035150547 01/05/2002 33 Citations

Gene transfer in the cardiovascular system: update 2000. (Medin JA, Buttrick PM) Heart Dis 2000;2(6):409-21 PMID: 11728292 SCOPUS ID: 2-s2.0-0034332591 12/01/2001 2 Citations

A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling. (Veldman RJ, Maestre N, Aduib OM, Medin JA, Salvayre R, Levade T) Biochem J 2001 May 01;355(Pt 3):859-68 PMID: 11311151 PMCID: PMC1221804 SCOPUS ID: 2-s2.0-0035340071 04/20/2001 99 Citations

Preselective gene therapy for Fabry disease. (Qin G, Takenaka T, Telsch K, Kelley L, Howard T, Levade T, Deans R, Howard BH, Malech HL, Brady RO, Medin JA) Proc Natl Acad Sci U S A 2001 Mar 13;98(6):3428-33 PMID: 11248095 PMCID: PMC30670 SCOPUS ID: 2-s2.0-0035853120 03/15/2001 68 Citations

Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells. (Takenaka T, Murray GJ, Qin G, Quirk JM, Ohshima T, Qasba P, Clark K, Kulkarni AB, Brady RO, Medin JA) Proc Natl Acad Sci U S A 2000 Jun 20;97(13):7515-20 PMID: 10840053 PMCID: PMC16577 SCOPUS ID: 2-s2.0-12944269059 06/07/2000 91 Citations

Stress-induced apoptosis is not mediated by endolysosomal ceramide. (Ségui B, Bezombes C, Uro-Coste E, Medin JA, Andrieu-Abadie N, Augé N, Brouchet A, Laurent G, Salvayre R, Jaffrézou JP, Levade T) FASEB J 2000 Jan;14(1):36-47 PMID: 10627278 SCOPUS ID: 2-s2.0-0038035591 01/08/2000 51 Citations

Circulating alpha-galactosidase A derived from transduced bone marrow cells: relevance for corrective gene transfer for Fabry disease. (Takenaka T, Qin G, Brady RO, Medin JA) Hum Gene Ther 1999 Aug 10;10(12):1931-9 PMID: 10466627 SCOPUS ID: 2-s2.0-0033543108 08/31/1999 45 Citations

Enzymatic and functional correction along with long-term enzyme secretion from transduced bone marrow hematopoietic stem/progenitor and stromal cells derived from patients with Fabry disease. (Takenaka T, Hendrickson CS, Tworek DM, Tudor M, Schiffmann R, Brady RO, Medin JA) Exp Hematol 1999 Jul;27(7):1149-59 PMID: 10390190 SCOPUS ID: 2-s2.0-0033019187 07/02/1999 38 Citations

Ex vivo expansion and genetic marking of primitive human and baboon hematopoietic cells. (Medin JA, Brandt JE, Rozler E, Nelson M, Bartholomew A, Li C, Turian J, Chute J, Chung T, Hoffman R) Ann N Y Acad Sci 1999 Apr 30;872:233-40; discussion 240-2 PMID: 10372126 SCOPUS ID: 2-s2.0-0033063141 06/18/1999 6 Citations

Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells. (Medin JA, Takenaka T, Carpentier S, Garcia V, Basile JP, Segui B, Andrieu-Abadie N, Auge N, Salvayre R, Levade T) Hum Gene Ther 1999 May 20;10(8):1321-9 PMID: 10365663 SCOPUS ID: 2-s2.0-0033587181 06/12/1999 31 Citations

Characterization of the chimeric retinoic acid receptor RARalpha/VDR. (Pemrick SM, Abarzúa P, Kratzeisen C, Marks MS, Medin JA, Ozato K, Grippo JF) Leukemia 1998 Apr;12(4):554-62 PMID: 9557614 SCOPUS ID: 2-s2.0-0031978382 04/29/1998 6 Citations

Extending metabolic cooperativity in gene transfer for fabry disease: Transduction of patient bone marrow cells leads to intracellular enzymatic correction and secretion (Takcnaka T, Hendrickson CS, Tudor M, Schulmann R, Brady RO, Medin JA) FASEB Journal 1997;11(9) SCOPUS ID: 2-s2.0-33750145479 12/01/1997

Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor. (Nuñez SB, Medin JA, Braissant O, Kemp L, Wahli W, Ozato K, Segars JH) Mol Cell Endocrinol 1997 Mar 14;127(1):27-40 PMID: 9099898 SCOPUS ID: 2-s2.0-0343742625 03/14/1997 92 Citations

Viral vectors for gene therapy of hematopoietic cells. (Medin JA, Karlsson S) Immunotechnology 1997 Mar;3(1):3-19 PMID: 9154464 SCOPUS ID: 2-s2.0-0030951133 03/01/1997 20 Citations

Selection of retrovirally transduced cells to enhance the efficiency of gene therapy. (Medin JA, Karlsson S) Proc Assoc Am Physicians 1997 Mar;109(2):111-9 PMID: 9069579 SCOPUS ID: 2-s2.0-0030899477 03/01/1997 11 Citations

Gene therapy for fabry disease: Expression, secretion and uptake of a-galactosidase a (α-gal A) driven by a high titer recombinant retroviral vector (Medin JA, Tudor M, Simovitch R, Quirk JM, Tacobson S, Murray GJ, Brady RO) FASEB Journal 1996;10(6) SCOPUS ID: 2-s2.0-33748917449 12/01/1996

Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high-titer recombinant retroviral vector. (Medin JA, Tudor M, Simovitch R, Quirk JM, Jacobson S, Murray GJ, Brady RO) Proc Natl Acad Sci U S A 1996 Jul 23;93(15):7917-22 PMID: 8755577 PMCID: PMC38849 SCOPUS ID: 2-s2.0-0029836764 07/23/1996 69 Citations

A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients. (Medin JA, Migita M, Pawliuk R, Jacobson S, Amiri M, Kluepfel-Stahl S, Brady RO, Humphries RK, Karlsson S) Blood 1996 Mar 01;87(5):1754-62 PMID: 8634421 SCOPUS ID: 2-s2.0-0030028313 03/01/1996 39 Citations

Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors. (Migita M, Medin JA, Pawliuk R, Jacobson S, Nagle JW, Anderson S, Amiri M, Humphries RK, Karlsson S) Proc Natl Acad Sci U S A 1995 Dec 19;92(26):12075-9 PMID: 8618847 PMCID: PMC40299 SCOPUS ID: 2-s2.0-0029558180 12/19/1995 52 Citations

Transfer of the human glucocerebrosidase gene into hematopoietic stem cells of nonablated recipients: successful engraftment and long-term expression of the transgene. (Schiffmann R, Medin JA, Ward JM, Stahl S, Cottler-Fox M, Karlsson S) Blood 1995 Aug 01;86(3):1218-27 PMID: 7620175 SCOPUS ID: 2-s2.0-0029152181 08/01/1995 43 Citations

Retinoid X receptor beta and peroxisome proliferator-activated receptor activate an estrogen response element. (Nunez SB, Medin JA, Keller H, Wang K, Ozato K, Wahli W, Segars J) Recent Prog Horm Res 1995;50:409-16 PMID: 7740175 SCOPUS ID: 2-s2.0-0029202911 01/01/1995 19 Citations

Expression of foreign proteins in Trichoplusia ni larvae. (Medin JA, Gathy K, Coleman MS) Methods Mol Biol 1995;39:265-75 PMID: 7620555 SCOPUS ID: 2-s2.0-0029187610 01/01/1995 13 Citations

Quantitative increases in DNA binding affinity and positional effects determine 9-cis retinoic acid induced activation of the retinoid X receptor beta homodimer. (Medin JA, Minucci S, Driggers PH, Lee IJ, Ozato K) Mol Cell Endocrinol 1994 Oct;105(1):27-35 PMID: 7821715 SCOPUS ID: 2-s2.0-0027992329 10/01/1994 17 Citations

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. (Bovolenta C, Driggers PH, Marks MS, Medin JA, Politis AD, Vogel SN, Levy DE, Sakaguchi K, Appella E, Coligan JE) Proc Natl Acad Sci U S A 1994 May 24;91(11):5046-50 PMID: 8197182 PMCID: PMC43928 SCOPUS ID: 2-s2.0-0028229886 05/24/1994 167 Citations

Recombinant thyroid hormone receptor and retinoid X receptor stimulate ligand-dependent transcription in vitro. (Lee IJ, Driggers PH, Medin JA, Nikodem VM, Ozato K) Proc Natl Acad Sci U S A 1994 Mar 01;91(5):1647-51 PMID: 8127860 PMCID: PMC43220 SCOPUS ID: 2-s2.0-0028194869 03/01/1994 30 Citations

Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids. (Krey G, Keller H, Mahfoudi A, Medin J, Ozato K, Dreyer C, Wahli W) J Steroid Biochem Mol Biol 1993 Dec;47(1-6):65-73 PMID: 8274443 SCOPUS ID: 2-s2.0-0027753736 12/01/1993 89 Citations

Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers. (Segars JH, Nagata T, Bours V, Medin JA, Franzoso G, Blanco JC, Drew PD, Becker KG, An J, Tang T) Mol Cell Biol 1993 Oct;13(10):6157-69 PMID: 8413217 PMCID: PMC364675 SCOPUS ID: 2-s2.0-0027452408 10/01/1993 69 Citations

Peroxisome proliferator-activated receptors and lipid metabolism. (Keller H, Mahfoudi A, Dreyer C, Hihi AK, Medin J, Ozato K, Wahli W) Ann N Y Acad Sci 1993 Jun 11;684:157-73 PMID: 8391237 SCOPUS ID: 2-s2.0-0027275024 06/11/1993 83 Citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. (Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W) Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2160-4 PMID: 8384714 PMCID: PMC46045 SCOPUS ID: 2-s2.0-0027447461 03/15/1993 895 Citations

Mutational analysis of active site residues of human adenosine deaminase. (Bhaumik D, Medin J, Gathy K, Coleman MS) J Biol Chem 1993 Mar 15;268(8):5464-70 PMID: 8449909 SCOPUS ID: 2-s2.0-0027456581 03/15/1993 51 Citations

Lack of functional significance of Cys227 and Cys234 in terminal deoxynucleotidyltransferase. (Medin JA, Coleman MS) J Biol Chem 1992 Mar 15;267(8):5199-201 PMID: 1544903 SCOPUS ID: 2-s2.0-0026657777 03/15/1992 3 Citations

Efficient, low-cost protein factories: expression of human adenosine deaminase in baculovirus-infected insect larvae. (Medin JA, Hunt L, Gathy K, Evans RK, Coleman MS) Proc Natl Acad Sci U S A 1990 Apr;87(7):2760-4 PMID: 2181448 PMCID: PMC53770 SCOPUS ID: 2-s2.0-0025349629 04/01/1990 72 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Jeffrey A. Medin PhD

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Publications (181)