Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. J Neuroimmunol 2010 Oct 08;227(1-2):162-6
Date
07/06/2010Pubmed ID
20598377DOI
10.1016/j.jneuroim.2010.06.003Scopus ID
2-s2.0-77956649792 (requires institutional sign-in at Scopus site) 62 CitationsAbstract
In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.
Author List
Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Roeske D, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, Weber FAuthor
Antje Kroner-Milsch MD, PhD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Case-Control Studies
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA Antigens
Humans
Male
Middle Aged
Multiple Sclerosis
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-vav
Repressor Proteins
Young Adult
Zinc Fingers