Faculty Collaboration Database

The genetic influence of the nonclassical MHC molecule HLA-G on multiple sclerosis. Hum Immunol 2007 May;68(5):422-5

Date

04/28/2007

Pubmed ID

17462509

DOI

10.1016/j.humimm.2007.01.012

Scopus ID

2-s2.0-34247234404 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

Human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex (MHC) molecule located at MHC complex at chromosome 6 and chiefly attributed immunoregulatory and tolerogenic functions. HLA-G is upregulated at sites of inflammation in multiple sclerosis (MS) and assumed to counterbalance immune responses. Different functionally relevant genetic variants of HLA-G have been described and shown to be statistically associated with human diseases such as fetal loss or sarcoidosis. We investigated the influence of three different variations in the HLA-G gene for disease susceptibility and course of MS (n = 698): (1) The -725 C/G exchange in the HLA-G promoter region, (2) HLA-G*0105N, a deletion that results in an irregular stopcodon in exon 3, and (3) a 14 bp insertion / deletion in the untranslated exon 8. None of these variations significantly influenced the susceptibility to multiple sclerosis. No association was seen with the age of onset of disease, disease severity or disease course. Although HLA-G is assumed to play an important role in the immunoregulatory processes of MS, our results do not support a role of genetic factors influencing disease susceptibility of the disease course.

Author List

Kroner A, Grimm A, Johannssen K, Mäurer M, Wiendl H

Author

Antje Kroner-Milsch MD, PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

5' Untranslated Regions
Adolescent
Adult
Aged
Codon, Nonsense
Exons
Female
Frameshift Mutation
Gene Deletion
Gene Frequency
Genetic Predisposition to Disease
HLA Antigens
HLA-G Antigens
Histocompatibility Antigens Class I
Humans
Male
Middle Aged
Multiple Sclerosis
Multiple Sclerosis, Chronic Progressive
Multiple Sclerosis, Relapsing-Remitting
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Promoter Regions, Genetic