Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes in patients with multiple sclerosis and healthy controls. J Neuroimmunol 2006 Nov;180(1-2):185-92
Date
10/07/2006Pubmed ID
17023054DOI
10.1016/j.jneuroim.2006.08.008Scopus ID
2-s2.0-33750605408 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
The Epstein-Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS), however, the mechanisms by which EBV may be involved in MS are unknown. We here have investigated the frequency of EBV-specific cytotoxic T lymphocytes (CTL) in human leukocyte antigen (HLA)-B7(+) patients with MS and healthy controls using enzyme-linked immunospot assays and seven previously characterized HLA-B7-restricted immunogenic EBV peptides. Overall, there were no significant differences in the frequency of EBV-specific CTL between both groups. These data do not support the hypothesis that EBV could play a role in MS by inducing quantitatively altered EBV-specific CTL responses. Other pathogenic mechanisms for EBV in MS remain to be elucidated.
Author List
Gronen F, Ruprecht K, Weissbrich B, Klinker E, Kroner A, Hofstetter HH, Rieckmann PAuthor
Antje Kroner-Milsch MD, PhD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAntibodies, Viral
Antigens, Viral
Biomarkers
Cell Count
Cell Proliferation
Female
Genotype
HLA-B7 Antigen
Herpesvirus 4, Human
Humans
Immunity, Cellular
Lymphocyte Activation
Male
Middle Aged
Multiple Sclerosis
Reference Values
T-Lymphocytes, Cytotoxic
Tetanus Toxoid
Viral Load
