Faculty Collaboration Database

On the discriminatory value of anti-HPCA-1 (CD-34) in the differential diagnosis of benign and malignant cutaneous vascular proliferations. Am J Dermatopathol 1994 Aug;16(4):355-63

Date

08/01/1994

Pubmed ID

7526723

DOI

10.1097/00000372-199408000-00001

Scopus ID

2-s2.0-0028108564 (requires institutional sign-in at Scopus site)   45 Citations

Abstract

The staining pattern of monoclonal antibody anti-HPCA-1 (CD-34) was studied in 95 cases of benign and malignant cutaneous vascular proliferations and compared with other vascular endothelium-associated antigenic markers in paraffin-embedded tissues. The proliferating vessels in 22 cutaneous capillary hemangiomas, 8 lobular capillary hemangiomas, and 1 case of papillary intravascular endothelial hyperplasia stained strongly positively for anti-HPCA-1, and the intensity of the reaction was paralleled by that of factor VIII-related antigen (FVIII), Ulex europaeus lectin-1 (UEA), and vimentin (VIM). The vessels in 10 cases of granulation tissue, 6 cases of cavernous hemangioma, 6 cases of angiokeratoma, 5 cases of angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma), and 3 cases of bacillary angiomatosis showed a lack of reactivity with anti-HPCA-1 and staining of variable intensity with the other markers. Twenty cases of Kaposi's sarcoma (seven patch, five plaque, eight nodular stage) showed strong labeling with anti-HPCA-1 in small, well-formed vessels scattered among the spindle-cell proliferation, and four of these cases showed focal positivity of scattered spindle cells. Nine cases of cutaneous angiosarcoma, two cases of low-grade epithelioid angiosarcoma, and one case of spindle-cell hemangioendothelioma were negative for anti-HPCA-1 and showed variable reactivity for FVIII and UEA; all cases stained strongly positively for VIM. The results of this study indicate that although anti-HPCA-1 shows a high sensitivity for the staining of normal vascular endothelium, its specificity may be restricted to mature, well-formed vessels, therefore rendering its discriminatory value very limited for the identification of poorly differentiated vascular endothelial neoplasms.

Author List

Suster S, Wong TY

MESH terms used to index this publication - Major topics in bold

Angiokeratoma
Angiomatosis, Bacillary
Antibodies, Monoclonal
Antigens, CD
Antigens, CD34
Biomarkers, Tumor
Diagnosis, Differential
Endothelium, Vascular
Granulation Tissue
Granuloma, Pyogenic
Hemangioendothelioma, Epithelioid
Hemangioma
Hemangioma, Capillary
Hemangioma, Cavernous
Hemangiosarcoma
Humans
Hyperplasia
Lectins
Paraffin Embedding
Plant Lectins
Sarcoma, Kaposi
Skin Diseases, Vascular
Skin Neoplasms
Staining and Labeling
Vimentin
von Willebrand Factor