Faculty Collaboration Database

Morbidity and mortality attributable to Rothia bacteremia in neutropenic and nonneutropenic patients. Diagn Microbiol Infect Dis 2016 May;85(1):116-20

Date

02/26/2016

Pubmed ID

26906191

DOI

10.1016/j.diagmicrobio.2016.01.005

Scopus ID

2-s2.0-84959066272 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

Rothia spp. are increasingly being recognized as emerging opportunistic pathogens associated with serious infections in immune-compromised hosts. Risk factors include neutropenia, hematologic malignancies, prosthetic devices, and intravascular catheters. We describe 29 patients at our institute from 2006 to 2014 with positive blood cultures for Rothia spp. Neutropenia was observed in 21/29 (72%) patients at the time of bacteremia, and 16/29 (61%) had leukemia. Neutropenic patients were less likely than nonneutropenic patients to have polymicrobial infection (24% versus 63%; P= 0.083) and were also more likely to have multiple positive blood cultures (76% versus 0%; P= 0.0003), indicating true infection. Sources of bacteremia included intravascular catheters, mucositis, and presumed gut translocation. A significant association was seen with steroid use (81% versus 13%; P= 0.0014) and fluoroquinolone use (86% versus 13%; P≤ 0.0001) preceding bacteremia in neutropenic patients. There was no difference between the 2 groups for admission to intensive care unit or mortality. One death was reported possibly due to Rothia infection.

Author List

Abidi MZ, Ledeboer N, Banerjee A, Hari P

Authors

Anjishnu Banerjee PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin
Parameswaran Hari MD Adjunct Professor in the Medicine department at Medical College of Wisconsin
Nathan A. Ledeboer PhD Vice Chair, Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Anti-Bacterial Agents
Bacteremia
Comorbidity
Female
Gram-Positive Bacterial Infections
Hematologic Neoplasms
Humans
Incidence
Male
Micrococcaceae
Middle Aged
Morbidity
Mortality
Neutropenia
Retrospective Studies
Stem Cell Transplantation