Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency. Virology 2016 May;492:140-4
Date
03/06/2016Pubmed ID
26945150Pubmed Central ID
PMC4826794DOI
10.1016/j.virol.2016.02.022Scopus ID
2-s2.0-84959386532 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology.
Author List
Rekow MM, Darrah EJ, Mboko WP, Lange PT, Tarakanova VLAuthor
Vera Tarakanova PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsB-Lymphocyte Subsets
Gammaherpesvirinae
Herpesviridae Infections
Host-Pathogen Interactions
Mice
Mice, Inbred C57BL
Myeloid Cells
Peritoneum
Spleen
Virus Activation
Virus Latency