Faculty Collaboration Database

Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency. Virology 2016 May;492:140-4

Date

03/06/2016

Pubmed ID

26945150

Pubmed Central ID

PMC4826794

DOI

10.1016/j.virol.2016.02.022

Scopus ID

2-s2.0-84959386532   11 Citations

Abstract

Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology.

Author List

Rekow MM, Darrah EJ, Mboko WP, Lange PT, Tarakanova VL

Author

Vera Tarakanova PhD Associate Professor in the Microbiology and Immunology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
B-Lymphocyte Subsets
Gammaherpesvirinae
Herpesviridae Infections
Host-Pathogen Interactions
Mice
Mice, Inbred C57BL
Myeloid Cells
Peritoneum
Spleen
Virus Activation
Virus Latency