Faculty Collaboration Database

Recovery time course in contractile function of fast and slow skeletal muscle after hindlimb immobilization. J Appl Physiol Respir Environ Exerc Physiol 1982 Mar;52(3):677-82

Date

03/01/1982

Pubmed ID

7068483

DOI

10.1152/jappl.1982.52.3.677

Scopus ID

2-s2.0-0019968594 (requires institutional sign-in at Scopus site)   63 Citations

Abstract

Contractile properties were evaluated in rats remobilized after 6 wk of hindlimb casting to evaluate the regenerative capacity of fast and slow skeletal muscles. Contractile parameters were determined in vitro (22 degrees C) in the type I soleus (SOL), type IIA and IIB extensor digitorum longus (EDL), and the type IIB superficial vastus lateralis (SVL). Immobilization (IM) shortened the SOL isometric twitch duration after which contraction time and half-relaxation time required 4 and 7 days to recover, respectively. In contrast, IM prolonged the twitch in the EDL and SVL and recovery required 14 and 7 days, respectively. Peak tetanic tension (g/cm2) fell in the SOL and EDL with IM and full recovery required 28 days. In this regard, the SVL remained unaltered. Rates of tension development and decline remained essentially unaltered in the fast muscles after IM but fell in the SOL, requiring 14 days to fully recover. Maximal shortening velocity, which had been elevated in all three muscles by IM, recovered rapidly. The present results demonstrate that both fast and slow muscle have the ability to completely recover from 6 weeks of IM.

Author List

Witzmann FA, Kim DH, Fitts RH

Author

Robert Fitts PhD Professor in the Biological Sciences department at Marquette University

MESH terms used to index this publication - Major topics in bold

Animals
Female
Hindlimb
Immobilization
Muscle Contraction
Muscle Tonus
Muscles
Rats
Rats, Inbred Strains
Regeneration
Time Factors