Faculty Collaboration Database

Effect of exercise on response of liver lipogenic enzymes to a high fructose diet. Proc Soc Exp Biol Med 1975 Apr;148(4):1150-4

Date

04/01/1975

Pubmed ID

236576

DOI

10.3181/00379727-148-38706

Scopus ID

2-s2.0-0016710115 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Meal-fed Long-Evans rats fed a high fructose diet and exercised for 2-hr daily on a treadmill for three days had lower levels of several hepatic lipogenic enzymes (acetyl CoA carboxylase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, malic enzyme and citrate cleavage enzyme) than did sedentary rats pair-fed the diet. Accumulation of triglycerides in plasma following ingestion of a fat-free, high fructose meal and injection of Triton WR-1339, an inhibitor of plasma triglyceride clearance, was not significantly different in the two groups of animals. All of the hepatic lipogenic enzymes measured, with the exception of citrate cleavage enzyme, attained similar levels in the runners as in the controls after 5 days on the high fructose diet. Thus the exercise appeared to affect the time course of the increase in the levels of activity of most of the lipogenic enzymes but not the final steady state levels attained.

Author List

Winder WW, Booth FW, Fitts RH, Holloszy JO

Author

Robert Fitts PhD Professor in the Biological Sciences department at Marquette University

MESH terms used to index this publication - Major topics in bold

Acetyl-CoA Carboxylase
Alcohol Oxidoreductases
Animals
Dietary Carbohydrates
Dietary Fats
Fructose
Glucosephosphate Dehydrogenase
Ligases
Liver
Malate Dehydrogenase
Male
Phosphogluconate Dehydrogenase
Physical Exertion
Polyethylene Glycols
Rats
Time Factors
Triglycerides