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Airway reflux. Ann N Y Acad Sci 2016 10;1381(1):5-13

Date

10/28/2016

Pubmed ID

27310222

DOI

10.1111/nyas.13080

Scopus ID

2-s2.0-84977120378   22 Citations

Abstract

An ever-increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and complicated aspect of medicine that requires a multidisciplinary approach. Evidence indicates that it is not only the acidic components of gastric refluxate that injure extraesophageal tissues but also the nonacidic components, such as pepsin and bile. There is a realization that proton pump inhibitors will not be effective when nonacidic components of refluxate are causing the problem. New in vitro and in vivo models for the study of airway reflux and new therapeutic and surgical approaches are discussed in this review article.

Author List

Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW

Authors

Jon Gould MD Chief, Professor in the Surgery department at Medical College of Wisconsin
Nikki Johnston PhD Associate Professor in the Otolaryngology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Biomarkers
Esophageal pH Monitoring
Gastroesophageal Reflux
Humans
Laryngopharyngeal Reflux
Laryngoscopy
Pepsin A
Proton Pump Inhibitors
Sinusitis
jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280