Airway reflux. Ann N Y Acad Sci 2016 Oct;1381(1):5-13
Date
10/28/2016Pubmed ID
27310222DOI
10.1111/nyas.13080Scopus ID
2-s2.0-84977120378 (requires institutional sign-in at Scopus site) 46 CitationsAbstract
An ever-increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and complicated aspect of medicine that requires a multidisciplinary approach. Evidence indicates that it is not only the acidic components of gastric refluxate that injure extraesophageal tissues but also the nonacidic components, such as pepsin and bile. There is a realization that proton pump inhibitors will not be effective when nonacidic components of refluxate are causing the problem. New in vitro and in vivo models for the study of airway reflux and new therapeutic and surgical approaches are discussed in this review article.
Author List
Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KWAuthors
Jon Gould MD Chief, Professor in the Surgery department at Medical College of WisconsinNikki Johnston PhD Professor in the Otolaryngology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBiomarkers
Esophageal pH Monitoring
Gastroesophageal Reflux
Humans
Laryngopharyngeal Reflux
Laryngoscopy
Pepsin A
Proton Pump Inhibitors
Sinusitis