Faculty Collaboration Database

Medical College of Wisconsin

CTSI Cores Search Research Informatics REDCap

Nikki Johnston PhD

Professor

Institution: Medical College of Wisconsin
Department: Otolaryngology
Program: Adult

Member of the Cancer Center
Member of the Mellowes Center for Genomic Sciences and Precision Medicine

Send Message

Request Meeting

View Curriculum Vitae

Publications (94)

Unveiling the Silent Struggle: A Comprehensive Guide to Laryngopharyngeal Reflux Disease. (Husain IA, Johnston N) Otolaryngol Clin North Am 2025 Jun;58(3):xv-xvi PMID: 40185652 SCOPUS ID: 2-s2.0-105001827920 04/05/2025

Pepsin, Mucosal Injury, and Pathophysiology of Non-acid Reflux. (Samuels TL, Johnston N) Otolaryngol Clin North Am 2025 Jun;58(3):415-432 PMID: 40148170 SCOPUS ID: 2-s2.0-105001138800 03/28/2025

Advances in laryngopharyngeal reflux: Etiology, diagnosis, and management. (Samuels TL, Aoun J, Husain I, Figueredo E, Richards D, Johnston N) Ann N Y Acad Sci 2024 Nov;1541(1):53-62 PMID: 39420555 SCOPUS ID: 2-s2.0-85206825163 10/18/2024 4 Citations

Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease. (Ergun P, Samuels TL, Mathison AJ, Plehhova K, Coyle C, Horvath L, Johnston N) Int J Mol Sci 2024 Oct 05;25(19) PMID: 39409043 PMCID: PMC11605242 SCOPUS ID: 2-s2.0-85206446606 10/16/2024 3 Citations

17β-estradiol Attenuates the Middle Ear Inflammatory Response to Nontypeable Haemophilus influenzae. (Khampang P, Samuels TL, Blaine-Sauer S, Lucas J, Yan K, Johnston N, Kerschner JE) Laryngoscope 2024 Aug;134(8):3815-3819 PMID: 38401061 SCOPUS ID: 2-s2.0-85186458928 02/24/2024

Inhaled fosamprenavir for laryngopharyngeal reflux: Toxicology and fluid dynamics modeling. (Lesnick A, Samuels TL, Seabloom D, Wuertz B, Ojha A, Seelig D, Ondrey F, Wiedmann TS, Hogan C, Torii E, Ouyang H, Yan K, Garcia GJM, Bock JM, Johnston N) Laryngoscope Investig Otolaryngol 2024 Feb;9(1):e1219 PMID: 38362183 PMCID: PMC10866582 SCOPUS ID: 2-s2.0-85183005384 02/16/2024 7 Citations

Inhaled fosamprenavir for laryngopharyngeal reflux: Toxicology and fluid dynamics modeling (Lesnick A, Samuels TL, Seabloom D, Wuertz B, Ojha A, Seelig D, Ondrey F, Wiedmann TS, Hogan C, Torii E, Ouyang H, Yan K, Garcia GJM, Bock JM, Johnston N) Laryngoscope Investigative Otolaryngology February 2024;9(1) SCOPUS ID: 2-s2.0-85183005384 02/01/2024 7 Citations

The Dubai Definition and Diagnostic Criteria of Laryngopharyngeal Reflux: The IFOS Consensus. (Lechien JR, Vaezi MF, Chan WW, Allen JE, Karkos PD, Saussez S, Altman KW, Amin MR, Ayad T, Barillari MR, Belafsky PC, Blumin JH, Johnston N, Bobin F, Broadhurst M, Ceccon FP, Calvo-Henriquez C, Eun YG, Chiesa-Estomba CM, Crevier-Buchman L, Clarke JO, Dapri G, Eckley CA, Finck C, Fisichella PM, Hamdan AL, Hans S, Huet K, Imamura R, Jobe BA, Hoppo T, Maron LP, Muls V, O'Rourke AK, Perazzo PS, Postma G, Prasad VMN, Remacle M, Sant'Anna GD, Sataloff RT, Savarino EV, Schindler A, Siupsinskiene N, Tseng PH, Zalvan CH, Zelenik K, Fraysse B, Bock JM, Akst LM, Carroll TL) Laryngoscope 2024 Apr;134(4):1614-1624 PMID: 37929860 SCOPUS ID: 2-s2.0-85168811976 11/06/2023 63 Citations

Establishment of novel immortalized middle ear cell lines as models for otitis media. (Blaine-Sauer S, Samuels TL, Khampang P, Yan K, McCormick ME, Chun RH, Harvey SA, Friedland DR, Johnston N, Kerschner JE) Laryngoscope Investig Otolaryngol 2023 Oct;8(5):1428-1435 PMID: 37899851 PMCID: PMC10601576 SCOPUS ID: 2-s2.0-85168915314 10/30/2023 2 Citations

Establishment of novel immortalized middle ear cell lines as models for otitis media (Blaine-Sauer S, Samuels TL, Khampang P, Yan K, McCormick ME, Chun RH, Harvey SA, Friedland DR, Johnston N, Kerschner JE) Laryngoscope Investigative Otolaryngology October 2023;8(5):1428-1435 SCOPUS ID: 2-s2.0-85168915314 10/01/2023 2 Citations

Amprenavir inhibits pepsin-mediated laryngeal epithelial disruption and E-cadherin cleavage in vitro. (Samuels TL, Blaine-Sauer S, Yan K, Johnston N) Laryngoscope Investig Otolaryngol 2023 Aug;8(4):953-962 PMID: 37621274 PMCID: PMC10446255 SCOPUS ID: 2-s2.0-85168617410 08/25/2023 8 Citations

Topical Alginate Protection against Pepsin-Mediated Esophageal Damage: E-Cadherin Proteolysis and Matrix Metalloproteinase Induction. (Samuels TL, Blaine-Sauer S, Yan K, Plehhova K, Coyle C, Johnston N) Int J Mol Sci 2023 Apr 27;24(9) PMID: 37175640 PMCID: PMC10178445 SCOPUS ID: 2-s2.0-85152786973 05/13/2023 8 Citations

The Protease Inhibitor Amprenavir Protects against Pepsin-Induced Esophageal Epithelial Barrier Disruption and Cancer-Associated Changes. (Blaine-Sauer S, Samuels TL, Yan K, Johnston N) Int J Mol Sci 2023 Apr 05;24(7) PMID: 37047737 PMCID: PMC10095080 SCOPUS ID: 2-s2.0-85152307105 04/14/2023 11 Citations

Cancer Risk in Barrett's Esophagus: A Clinical Review. (Beydoun AS, Stabenau KA, Altman KW, Johnston N) Int J Mol Sci 2023 Mar 23;24(7) PMID: 37046992 PMCID: PMC10094310 SCOPUS ID: 2-s2.0-85152314734 04/14/2023 13 Citations

Association of e-Cigarette Exposure with Pediatric Otitis Media Recurrence. (Lam TK, Samuels TL, Yan K, Zhang L, Adams J, Stabenau KA, Kerschner JE, Johnston N) Ann Otol Rhinol Laryngol 2023 Sep;132(9):1018-1025 PMID: 36217957 SCOPUS ID: 2-s2.0-85139551804 10/12/2022

Correlation of Esophageal Mean Nocturnal Baseline Impedance With Markers of Laryngopharyngeal Reflux. (Kurylo CM, Eastwood D, Blumin JH, Johnston N, Bock JM) Laryngoscope 2023 Aug;133(8):1927-1932 PMID: 36196929 SCOPUS ID: 2-s2.0-85139205806 10/06/2022 5 Citations

Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model. (Johnston N, Samuels TL, Goetz CJ, Arnold LA, Smith BC, Seabloom D, Wuertz B, Ondrey F, Wiedmann TS, Vuksanovic N, Silvaggi NR, MacKinnon AC, Miller J, Bock J, Blumin JH) Laryngoscope 2023 Jan;133 Suppl 1(Suppl 1):S1-S11 PMID: 35678265 PMCID: PMC9732152 SCOPUS ID: 2-s2.0-85131512635 06/10/2022 13 Citations

Pepsinogen/Proton Pump Co-Expression in Barrett's Esophageal Cells Induces Cancer-Associated Changes. (Stabenau KA, Samuels TL, Lam TK, Mathison AJ, Wells C, Altman KW, Battle MA, Johnston N) Laryngoscope 2023 Jan;133(1):59-69 PMID: 35315085 SCOPUS ID: 2-s2.0-85126774243 03/23/2022 8 Citations

Alginates for Protection Against Pepsin-Acid Induced Aerodigestive Epithelial Barrier Disruption. (Samuels TL, Yan K, Patel N, Plehhova K, Coyle C, Hurley BP, Johnston N) Laryngoscope 2022 Dec;132(12):2327-2334 PMID: 35238407 SCOPUS ID: 2-s2.0-85125521274 03/04/2022 11 Citations

How I Approach Laryngopharyngoesophageal Reflux (LPR). (Stabenau K, Johnston N) Curr Gastroenterol Rep 2021 Nov 19;23(12):27 PMID: 34799757 SCOPUS ID: 2-s2.0-85119598515 11/21/2021 6 Citations

Association of Pepsin With Inflammatory Signaling and Effusion Viscosity in Pediatric Otitis Media. (Samuels TL, Khampang P, Espahbodi M, McCormick CA, Chun RH, McCormick ME, Yan K, Kerschner JE, Johnston N) Laryngoscope 2022 Feb;132(2):470-477 PMID: 34272879 SCOPUS ID: 2-s2.0-85110911486 07/18/2021 13 Citations

RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media. (Stabenau KA, Zimmermann MT, Mathison A, Zeighami A, Samuels TL, Chun RH, Papsin BC, McCormick ME, Johnston N, Kerschner JE) Laryngoscope 2021 Nov;131(11):2590-2597 PMID: 33844317 SCOPUS ID: 2-s2.0-85104152095 04/13/2021 9 Citations

Pepsin in gastroesophageal and extraesophageal reflux: molecular pathophysiology and diagnostic utility. (Samuels TL, Johnston N) Curr Opin Otolaryngol Head Neck Surg 2020 Dec;28(6):401-409 PMID: 33060393 SCOPUS ID: 2-s2.0-85094932824 10/17/2020 26 Citations

Analysis of Inflammatory Signaling in Human Middle Ear Cell Culture Models of Pediatric Otitis Media. (Espahbodi M, Samuels TL, McCormick C, Khampang P, Yan K, Marshall S, McCormick ME, Chun RH, Harvey SA, Friedland DR, Johnston N, Kerschner JE) Laryngoscope 2021 Feb;131(2):410-416 PMID: 32433794 SCOPUS ID: 2-s2.0-85085010563 05/21/2020 10 Citations

Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations. (Klimara MJ, Randall DR, Allen J, Figueredo E, Johnston N) Ann N Y Acad Sci 2020 Dec;1481(1):127-138 PMID: 32401362 SCOPUS ID: 2-s2.0-85097874970 05/14/2020 25 Citations

H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients. (McCormick CA, Samuels TL, Battle MA, Frolkis T, Blumin JH, Bock JM, Wells C, Yan K, Altman KW, Johnston N) Laryngoscope 2021 Jan;131(1):130-135 PMID: 32250454 SCOPUS ID: 2-s2.0-85083103241 04/07/2020 16 Citations

RNA Sequencing Reveals Cancer-Associated Changes in Laryngeal Cells Exposed to Non-Acid Pepsin. (Samuels TL, Zimmermann MT, Zeighami A, Demos W, Southwood JE, Blumin JH, Bock JM, Johnston N) Laryngoscope 2021 Jan;131(1):121-129 PMID: 32202667 SCOPUS ID: 2-s2.0-85082674385 03/24/2020 31 Citations

Detection of Pepsin in Oral Secretions of Infants with and without Laryngomalacia. (Klimara MJ, Samuels TL, Johnston N, Chun RH, McCormick ME) Ann Otol Rhinol Laryngol 2020 Mar;129(3):224-229 PMID: 31631681 SCOPUS ID: 2-s2.0-85074441413 10/22/2019 10 Citations

Pepsin Triggers Neutrophil Migration Across Acid Damaged Lung Epithelium. (Hurley BP, Jugo RH, Snow RF, Samuels TL, Yonker LM, Mou H, Johnston N, Rosen R) Sci Rep 2019 Sep 24;9(1):13778 PMID: 31551494 PMCID: PMC6760148 SCOPUS ID: 2-s2.0-85072622956 09/26/2019 30 Citations

Correlation of salivary and nasal lavage pepsin with MII-pH testing. (Klimara MJ, Johnston N, Samuels TL, Visotcky AM, Poetker DM, Loehrl TA, Blumin JH, Bock JM) Laryngoscope 2020 Apr;130(4):961-966 PMID: 31329290 SCOPUS ID: 2-s2.0-85069855612 07/23/2019 36 Citations

Detection of pepsin and IL-8 in saliva of adult asthmatic patients. (Marshall S, McCann AJ, Samuels TL, Blair A, Bonne V, Johnston N, Koufman J) J Asthma Allergy 2019;12:155-161 PMID: 31213853 PMCID: PMC6549784 SCOPUS ID: 2-s2.0-85070530285 06/20/2019 7 Citations

Esophageal pepsin and proton pump synthesis in barrett's esophagus and esophageal adenocarcinoma. (Samuels TL, Altman KW, Gould JC, Kindel T, Bosler M, MacKinnon A, Hagen CE, Johnston N) Laryngoscope 2019 Dec;129(12):2687-2695 PMID: 31046139 SCOPUS ID: 2-s2.0-85065403373 05/03/2019 17 Citations

The role of pepsin in epithelia-mesenchymal transition in idiopathic subglottic stenosis. (McCann AJ, Samuels TL, Blumin JH, Johnston N) Laryngoscope 2020 Jan;130(1):154-158 PMID: 30776094 SCOPUS ID: 2-s2.0-85061936635 02/19/2019 15 Citations

Pepsin: biomarker, mediator, and therapeutic target for reflux and aspiration. (Johnston N, Dettmar PW, Ondrey FG, Nanchal R, Lee SH, Bock JM) Ann N Y Acad Sci 2018 Dec;1434(1):282-289 PMID: 29774546 SCOPUS ID: 2-s2.0-85047661971 05/19/2018 38 Citations

Incidence and risk of aspiration in mechanically ventilated patients (Klimara MJ, Nanchal R, Johnston N) Reflux Aspiration and Lung Disease 1 January 2018:235-244 SCOPUS ID: 2-s2.0-85064371769 01/01/2018

Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion. (Samuels TL, Yan JC, Khampang P, Dettmar PW, MacKinnon A, Hong W, Johnston N, Papsin BC, Chun RH, McCormick ME, Kerschner JE) JAMA Otolaryngol Head Neck Surg 2017 Aug 01;143(8):810-817 PMID: 28594978 PMCID: PMC5710562 SCOPUS ID: 2-s2.0-85027729929 06/09/2017 24 Citations

Panel 8: Report on Recent Advances in Molecular and Cellular Biochemistry. (Preciado D, Granath A, Lin J, Val S, Kurabi A, Johnston N, Vijayasekaran S, Valdez T, Depireux D, Hermansson A) Otolaryngol Head Neck Surg 2017 Apr;156(4_suppl):S106-S113 PMID: 28372528 SCOPUS ID: 2-s2.0-85018984822 04/05/2017 5 Citations

Pepsin as a biomarker for laryngopharyngeal reflux in children with laryngomalacia. (Luebke K, Samuels TL, Chelius TH, Sulman CG, McCormick ME, Kerschner JE, Johnston N, Chun RH) Laryngoscope 2017 Oct;127(10):2413-2417 PMID: 28224634 SCOPUS ID: 2-s2.0-85013435856 02/23/2017 28 Citations

Airway reflux. (Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW) Ann N Y Acad Sci 2016 Oct;1381(1):5-13 PMID: 27310222 SCOPUS ID: 2-s2.0-84977120378 10/28/2016 49 Citations

Association of microRNA 146 with middle ear hyperplasia in pediatric otitis media. (Samuels TL, Yan J, Khampang P, MacKinnon A, Hong W, Johnston N, Kerschner JE) Int J Pediatr Otorhinolaryngol 2016 Sep;88:104-8 PMID: 27497395 PMCID: PMC4978186 SCOPUS ID: 2-s2.0-84979086846 08/09/2016 17 Citations

The Role of Pepsin in LPR: Will It Change Our Diagnostic and Therapeutic Approach to the Disease? (Luebke KE, Samuels TL, Johnston N) Current Otorhinolaryngology Reports March 2016;4(1):55-62 SCOPUS ID: 2-s2.0-85064366877 03/01/2016 6 Citations

Gastroesophageal Reflux Burden, Even in Children That Aspirate, Does Not Increase Pediatric Hospitalization. (Duncan DR, Amirault J, Johnston N, Mitchell P, Larson K, Rosen RL) J Pediatr Gastroenterol Nutr 2016 Aug;63(2):210-7 PMID: 26794490 PMCID: PMC4917472 SCOPUS ID: 2-s2.0-84979732334 01/23/2016 18 Citations

Valproic acid suppresses the self-renewal and proliferation of head and neck cancer stem cells. (Lee SH, Nam HJ, Kang HJ, Samuels TL, Johnston N, Lim YC) Oncol Rep 2015 Oct;34(4):2065-71 PMID: 26239260 SCOPUS ID: 2-s2.0-84939160349 08/05/2015 19 Citations

The Impact of Pepsin on Human Nasal Epithelial Cells In Vitro: A Potential Mechanism for Extraesophageal Reflux Induced Chronic Rhinosinusitis. (Southwood JE, Hoekzema CR, Samuels TL, Wells C, Poetker DM, Johnston N, Loehrl TA) Ann Otol Rhinol Laryngol 2015 Dec;124(12):957-64 PMID: 26127000 SCOPUS ID: 2-s2.0-84953378153 07/02/2015 25 Citations

Local Synthesis of Pepsin in Barrett's Esophagus and the Role of Pepsin in Esophageal Adenocarcinoma. (Samuels T, Hoekzema C, Gould J, Goldblatt M, Frelich M, Bosler M, Lee SH, Johnston N) Ann Otol Rhinol Laryngol 2015 Nov;124(11):893-902 PMID: 26077392 PMCID: PMC4750403 SCOPUS ID: 2-s2.0-84952334416 06/17/2015 17 Citations

Laryngopharyngeal reflux (Blumin JH, Johnston N) Bailey S Head and Neck Surgery Otolaryngology 3 November 2014;1-2:958-977 SCOPUS ID: 2-s2.0-85054511431 11/03/2014 2 Citations

Association between tracheal pepsin, a reliable marker of gastric aspiration, and head of bed elevation among ventilated neonates. (Garland JS, Alex CP, Johnston N, Yan JC, Werlin SL) J Neonatal Perinatal Med 2014 Jan 01;7(3):185-92 PMID: 25318633 SCOPUS ID: 2-s2.0-84909981710 10/17/2014 13 Citations

Establishment of an immortalized laryngeal posterior commissure cell line as a tool for reflux research. (Lee SH, Samuels T, Bock JM, Blumin JH, Johnston N) Laryngoscope 2015 Feb;125(2):E73-7 PMID: 25272366 SCOPUS ID: 2-s2.0-84921691276 10/02/2014 15 Citations

Upper esophageal and pharyngeal cancers. (Bock JM, Howell AB, Johnston N, Kresty LA, Lew D) Ann N Y Acad Sci 2014 Sep;1325:49-56 PMID: 25266014 PMCID: PMC4617690 SCOPUS ID: 2-s2.0-84928795440 10/01/2014 3 Citations

Differential response of gel-forming mucins to pathogenic middle ear bacteria. (Kerschner JE, Hong W, Khampang P, Johnston N) Int J Pediatr Otorhinolaryngol 2014 Aug;78(8):1368-73 PMID: 24958163 PMCID: PMC4104932 SCOPUS ID: 2-s2.0-84904036054 06/25/2014 22 Citations

Chronic pepsin exposure promotes anchorage-independent growth and migration of a hypopharyngeal squamous cell line. (Kelly EA, Samuels TL, Johnston N) Otolaryngol Head Neck Surg 2014 Apr;150(4):618-24 PMID: 24376122 PMCID: PMC4423599 SCOPUS ID: 2-s2.0-84899057392 01/01/2014 37 Citations

Curcumin and anthocyanin inhibit pepsin-mediated cell damage and carcinogenic changes in airway epithelial cells. (Samuels TL, Pearson AC, Wells CW, Stoner GD, Johnston N) Ann Otol Rhinol Laryngol 2013 Oct;122(10):632-41 PMID: 24294686 SCOPUS ID: 2-s2.0-84887079765 12/04/2013 26 Citations

The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing. (Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S) Pediatr Pulmonol 2014 Nov;49(11):1090-6 PMID: 24178927 SCOPUS ID: 2-s2.0-85006371146 11/02/2013 36 Citations

Laryngopharyngeal reflux and GERD. (Johnston N, Dettmar PW, Strugala V, Allen JE, Chan WW) Ann N Y Acad Sci 2013 Oct;1300:71-79 PMID: 24117635 SCOPUS ID: 2-s2.0-84885453970 10/15/2013 37 Citations

Prevalence of pediatric aspiration-associated extraesophageal reflux disease. (Kelly EA, Parakininkas DE, Werlin SL, Southern JF, Johnston N, Kerschner JE) JAMA Otolaryngol Head Neck Surg 2013 Oct;139(10):996-1001 PMID: 23989194 PMCID: PMC4764882 SCOPUS ID: 2-s2.0-84892386503 08/31/2013 22 Citations

Extra-esophageal reflux, NOSE score, and sleep quality in an adult clinic population. (Laohasiriwong S, Johnston N, Woodson BT) Laryngoscope 2013 Dec;123(12):3233-8 PMID: 23754257 SCOPUS ID: 2-s2.0-84888428865 06/12/2013 24 Citations

The pathophysiology of gastroesophageal reflux (Johnston N) Gastroesophageal Reflux and the Lung 1 January 2013:23-41 SCOPUS ID: 2-s2.0-85028588374 01/01/2013

Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease. (Koufman JA, Johnston N) Ann Otol Rhinol Laryngol 2012 Jul;121(7):431-4 PMID: 22844861 SCOPUS ID: 2-s2.0-84864130580 08/01/2012 58 Citations

Reproducibility of Salivary Pepsin: Clinic versus Home. (Laohasiriwong S, Johnston N, Woodson BT) Otolaryngol Head Neck Surg 2012 Aug;147(2 suppl):P195 PMID: 25718691 08/01/2012

Extra-Esophageal Reflux (EER) and Sleep Disorders. (Laohasiriwong S, Woodson BT, Johnston N) Otolaryngol Head Neck Surg 2012 Aug;147(2 suppl):P120 PMID: 25718434 08/01/2012

Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cells. (Johnston N, Yan JC, Hoekzema CR, Samuels TL, Stoner GD, Blumin JH, Bock JM) Laryngoscope 2012 Jun;122(6):1317-25 PMID: 22570308 PMCID: PMC3816638 SCOPUS ID: 2-s2.0-84861808837 05/10/2012 96 Citations

The role of extraesophageal reflux in medically and surgically refractory rhinosinusitis. (Loehrl TA, Samuels TL, Poetker DM, Toohill RJ, Blumin JH, Johnston N) Laryngoscope 2012 Jul;122(7):1425-30 PMID: 22539181 SCOPUS ID: 2-s2.0-84862871424 04/28/2012 50 Citations

Reflux aspiration in children with neurodisability--a significant problem, but can we measure it? (Trinick R, Johnston N, Dalzell AM, McNamara PS) J Pediatr Surg 2012 Feb;47(2):291-8 PMID: 22325378 SCOPUS ID: 2-s2.0-84856832049 02/14/2012 31 Citations

Novel drug targets for reflux disease (Johnston N) Effects Diagnosis and Management of Extra Esophageal Reflux January 2012:335-345 SCOPUS ID: 2-s2.0-84895383079 01/01/2012

Pepsin as a marker of extraesophageal reflux (Samuels TL, Johnston N) Effects Diagnosis and Management of Extra Esophageal Reflux January 2012:115-122 SCOPUS ID: 2-s2.0-84895377544 01/01/2012

Effects, diagnosis and management of extra-esophageal reflux (Johnston N, Toohill RJ) Effects Diagnosis and Management of Extra Esophageal Reflux January 2012:1-530 SCOPUS ID: 2-s2.0-84895354820 01/01/2012

Preface (Johnston N, Toohill RJ) Effects Diagnosis and Management of Extra Esophageal Reflux January 2012 SCOPUS ID: 2-s2.0-84895222649 01/01/2012

The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux. (Rosen R, Johnston N, Hart K, Khatwa U, Nurko S) Neurogastroenterol Motil 2012 Feb;24(2):129-33, e84-5 PMID: 22141343 PMCID: PMC3307906 SCOPUS ID: 2-s2.0-84855967292 12/07/2011 54 Citations

Hoarseness and chronic cough: would you suspect reflux? (Sana S, Sana M, Johnston N, Mittal SK) J Fam Pract 2011 Aug;60(8):458-62 PMID: 21814640 SCOPUS ID: 2-s2.0-80053625397 08/05/2011 5 Citations

Higher rate of bronchoalveolar lavage culture positivity in children with nonacid reflux and respiratory disorders. (Rosen R, Johnston N, Hart K, Khatwa U, Katz E, Nurko S) J Pediatr 2011 Sep;159(3):504-6 PMID: 21777922 PMCID: PMC3157561 SCOPUS ID: 2-s2.0-80051792183 07/23/2011 20 Citations

Pepsin detection in patients with laryngopharyngeal reflux before and after fundoplication. (Wassenaar E, Johnston N, Merati A, Montenovo M, Petersen R, Tatum R, Pellegrini C, Oelschlager B) Surg Endosc 2011 Dec;25(12):3870-6 PMID: 21695583 SCOPUS ID: 2-s2.0-81955161202 06/23/2011 45 Citations

Evidence of extraesophageal reflux in idiopathic subglottic stenosis. (Blumin JH, Johnston N) Laryngoscope 2011 Jun;121(6):1266-73 PMID: 21557240 SCOPUS ID: 2-s2.0-79958258640 05/11/2011 87 Citations

Review article: Uptake of pepsin at pH 7 - In non-acid reflux - Causes inflammatory, and perhaps even neoplastic, changes in the laryngopharynx (Johnston N) Alimentary Pharmacology and Therapeutics April 2011;33(SUPPL. 1):13-20 SCOPUS ID: 2-s2.0-79952288013 04/01/2011 10 Citations

Review article: Effects of pepsin and alginate in an animal model of squamous cell carcinoma (Allen J, Tinling SP, Johnston N, Belafsky P) Alimentary Pharmacology and Therapeutics April 2011;33(SUPPL. 1):21-28 SCOPUS ID: 2-s2.0-79952291445 04/01/2011 5 Citations

Review article: reflux and its consequences--the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9th International Symposium on Human Pepsin (ISHP) Kingston-upon-Hull, UK, 21-23 April 2010. (Pearson JP, Parikh S, Orlando RC, Johnston N, Allen J, Tinling SP, Johnston N, Belafsky P, Arevalo LF, Sharma N, Castell DO, Fox M, Harding SM, Morice AH, Watson MG, Shields MD, Bateman N, McCallion WA, van Wijk MP, Wenzl TG, Karkos PD, Belafsky PC) Aliment Pharmacol Ther 2011 Apr;33 Suppl 1:1-71 PMID: 21366630 SCOPUS ID: 2-s2.0-79958007520 03/05/2011 107 Citations

Analysis of pepsin in tracheoesophageal puncture sites. (Bock JM, Brawley MK, Johnston N, Samuels T, Massey BL, Campbell BH, Toohill RJ, Blumin JH) Ann Otol Rhinol Laryngol 2010 Dec;119(12):799-805 PMID: 21250551 SCOPUS ID: 2-s2.0-78649949414 01/22/2011 18 Citations

Role of non-acidic reflux in laryngeal injury and disease (Johnston N) Laryngeal Diseases Symptoms Diagnosis and Treatments 2010:89-99 SCOPUS ID: 2-s2.0-84892974666 12/01/2010

Rationale for targeting pepsin in the treatment of reflux disease. (Johnston N, Wells CW, Samuels TL, Blumin JH) Ann Otol Rhinol Laryngol 2010 Aug;119(8):547-58 PMID: 20860281 SCOPUS ID: 2-s2.0-77955385732 09/24/2010 79 Citations

Pepsin as a marker of extraesophageal reflux. (Samuels TL, Johnston N) Ann Otol Rhinol Laryngol 2010 Mar;119(3):203-8 PMID: 20392035 SCOPUS ID: 2-s2.0-77949427443 04/16/2010 109 Citations

Pepsin as a marker of extraesophageal reflux (Samuels TL, Johnston N) Annals of Otology Rhinology and Laryngology March 2010;119(3):203-208 SCOPUS ID: 2-s2.0-77949427443 01/01/2010 109 Citations

Pepsin as a causal agent of inflammation during nonacidic reflux. (Samuels TL, Johnston N) Otolaryngol Head Neck Surg 2009 Nov;141(5):559-63 PMID: 19861190 SCOPUS ID: 2-s2.0-70350501815 10/29/2009 124 Citations

Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cells. (Johnston N, Wells CW, Samuels TL, Blumin JH) Ann Otol Rhinol Laryngol 2009 Sep;118(9):677-85 PMID: 19810610 SCOPUS ID: 2-s2.0-70349438977 10/09/2009 148 Citations

Immunologic response of the laryngeal mucosa to extraesophageal reflux. (Birchall MA, Bailey M, Gutowska-Owsiak D, Johnston N, Inman CF, Stokes CR, Postma G, Pazmany L, Koufman JA, Phillips A, Rees LE) Ann Otol Rhinol Laryngol 2008 Dec;117(12):891-5 PMID: 19140534 SCOPUS ID: 2-s2.0-59649120967 01/15/2009 13 Citations

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. (Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N) Ann Otol Rhinol Laryngol 2008 Sep;117(9):688-95 PMID: 18834073 SCOPUS ID: 2-s2.0-54249092323 10/07/2008 62 Citations

The mucosal immune response to laryngopharyngeal reflux. (Rees LE, Pazmany L, Gutowska-Owsiak D, Inman CF, Phillips A, Stokes CR, Johnston N, Koufman JA, Postma G, Bailey M, Birchall MA) Am J Respir Crit Care Med 2008 Jun 01;177(11):1187-93 PMID: 18323539 PMCID: PMC2643204 SCOPUS ID: 2-s2.0-44449125150 03/08/2008 37 Citations

Receptor-mediated uptake of pepsin by laryngeal epithelial cells. (Johnston N, Wells CW, Blumin JH, Toohill RJ, Merati AL) Ann Otol Rhinol Laryngol 2007 Dec;116(12):934-8 PMID: 18217514 SCOPUS ID: 2-s2.0-37349028008 01/26/2008 114 Citations

Role of extra-esophageal reflux in chronic otitis media with effusion. (Crapko M, Kerschner JE, Syring M, Johnston N) Laryngoscope 2007 Aug;117(8):1419-23 PMID: 17585281 SCOPUS ID: 2-s2.0-34548462940 06/23/2007 92 Citations

Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. (Johnston N, Dettmar PW, Bishwokarma B, Lively MO, Koufman JA) Laryngoscope 2007 Jun;117(6):1036-9 PMID: 17417109 SCOPUS ID: 2-s2.0-34249873017 04/10/2007 234 Citations

Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. (Johnston N, Dettmar PW, Lively MO, Postma GN, Belafsky PC, Birchall M, Koufman JA) Ann Otol Rhinol Laryngol 2006 Jan;115(1):47-58 PMID: 16466100 SCOPUS ID: 2-s2.0-31144457906 02/10/2006 116 Citations

Laryngeal epithelial defenses against laryngopharyngeal reflux: investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin. (Gill GA, Johnston N, Buda A, Pignatelli M, Pearson J, Dettmar PW, Koufman J) Ann Otol Rhinol Laryngol 2005 Dec;114(12):913-21 PMID: 16425556 SCOPUS ID: 2-s2.0-29744443713 01/24/2006 102 Citations

Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. (Knight J, Lively MO, Johnston N, Dettmar PW, Koufman JA) Laryngoscope 2005 Aug;115(8):1473-8 PMID: 16094128 SCOPUS ID: 2-s2.0-23344449645 08/12/2005 125 Citations

Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. (Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J) Laryngoscope 2004 Dec;114(12):2129-34 PMID: 15564833 SCOPUS ID: 2-s2.0-10044275611 11/27/2004 201 Citations

Cell biology of laryngeal epithelial defenses in health and disease: further studies. (Johnston N, Bulmer D, Gill GA, Panetti M, Ross PE, Pearson JP, Pignatelli M, Axford SE, Dettmar PW, Koufman JA) Ann Otol Rhinol Laryngol 2003 Jun;112(6):481-91 PMID: 12834114 SCOPUS ID: 2-s2.0-0038516590 07/02/2003 174 Citations

Cell biology of laryngeal epithelial defenses in health and disease: preliminary studies. (Axford SE, Sharp N, Ross PE, Pearson JP, Dettmar PW, Panetti M, Koufman JA) Ann Otol Rhinol Laryngol 2001 Dec;110(12):1099-108 PMID: 11768697 SCOPUS ID: 2-s2.0-0035207176 01/05/2002 113 Citations

Last update: 05/28/2025

© 2025 Clinical & Translational Science Institute
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53223

Publication and ontology data from NCBI | Disclaimer and Copyright

This site is a collaborative effort of the Medical College of Wisconsin and the Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number 2UL1TR001436) at the National Institutes of Health (NIH).

Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Nikki Johnston PhD

Professor

Publications (94)