Hypercalcemia associated with dysregulation of 1,25-dihydroxyvitamin D in arthritis. J Endocrinol Invest 1992 Nov;15(10):771-5
Date
11/01/1992Pubmed ID
1491127DOI
10.1007/BF03347650Scopus ID
2-s2.0-0027058280 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
We describe an elderly man who presented with hypercalcemia associated with suppressed intact parathyroid hormone (PTH) levels. Despite renal insufficiency the circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) was in the upper part of the normal range. Known causes of hypercalcemia were absent and mild hypercalcemia with suppression of intact PTH persisted until after bilateral hip replacement for severe arthritis (1 year after presentation). After hip replacement the ionized calcium normalized, intact PTH normalized, and 1,25(OH)2D decreased markedly. We believe the abnormalities in mineral homeostasis were related to production of 1,25(OH)2D by inflammatory mononuclear cells associated with arthritis.
Author List
Shaker JL, Auger GE, Wendt PP, Findling JWAuthors
James W. Findling MD Professor in the Medicine department at Medical College of WisconsinJoseph L. Shaker MD Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AgedArthritis
Dihydroxycholecalciferols
Hip Prosthesis
Humans
Hypercalcemia
Male
Monocytes
Parathyroid Hormone