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Hypercalcemia associated with dysregulation of 1,25-dihydroxyvitamin D in arthritis. J Endocrinol Invest 1992 Nov;15(10):771-5

Date

11/01/1992

Pubmed ID

1491127

DOI

10.1007/BF03347650

Scopus ID

2-s2.0-0027058280 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

We describe an elderly man who presented with hypercalcemia associated with suppressed intact parathyroid hormone (PTH) levels. Despite renal insufficiency the circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) was in the upper part of the normal range. Known causes of hypercalcemia were absent and mild hypercalcemia with suppression of intact PTH persisted until after bilateral hip replacement for severe arthritis (1 year after presentation). After hip replacement the ionized calcium normalized, intact PTH normalized, and 1,25(OH)2D decreased markedly. We believe the abnormalities in mineral homeostasis were related to production of 1,25(OH)2D by inflammatory mononuclear cells associated with arthritis.

Author List

Shaker JL, Auger GE, Wendt PP, Findling JW

Authors

James W. Findling MD Professor in the Medicine department at Medical College of Wisconsin
Joseph L. Shaker MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Arthritis
Dihydroxycholecalciferols
Hip Prosthesis
Humans
Hypercalcemia
Male
Monocytes
Parathyroid Hormone