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Indomethacin-induced hyperkalemia in three patients with gouty arthritis. JAMA 1980 Sep 05;244(10):1127-8

Date

09/05/1980

Pubmed ID

7411769

DOI

10.1001/jama.1980.03310100045031

Scopus ID

2-s2.0-0018966934 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin. This complication may result from an inhibition of prostaglandin synthesis and consequent hyporeninemic hypoaidosteronism. Careful attention to renal function and potassium balance in patients receiving indomethacin or other nonsteroidal anti-inflammatory agents, particularly in those patients with diabetes mellitus or preexisting renal disease, will help prevent this potentially serious complication.

Author List

Findling JW, Beckstrom D, Rawsthorne L, Kozin F, Itskovitz H

Author

James W. Findling MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acute Disease
Acute Kidney Injury
Aged
Diabetes Mellitus
Female
Gout
Humans
Hyperkalemia
Indomethacin
Male
Middle Aged
Nephritis, Interstitial
Uric Acid