Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum. Am J Alzheimers Dis Other Demen 2016 Feb;31(1):68-75
Date
04/24/2015Pubmed ID
25904759Pubmed Central ID
PMC4913466DOI
10.1177/1533317515578257Scopus ID
2-s2.0-84954289594 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Degenerative brain changes in Alzheimer's disease may occur in reverse order of normal brain development based on the retrogenesis model. This study tested whether evidence of reverse myelination was observed in mild cognitive impairment (MCI) using a data-driven analytic approach based on life span developmental data. Whole-brain high-resolution diffusion tensor imaging scans were obtained for 31 patients with MCI and 79 demographically matched healthy older adults. Comparisons across corpus callosum (CC) regions of interest (ROIs) showed decreased fractional anisotropy (FA) in the body but not in the genu or splenium; early-, middle-, and late-myelinating ROIs restricted to the CC revealed decreased FA in late- but not early- or middle-myelinating ROIs. Voxelwise group differences revealed areas of lower FA in MCI, but whole-brain differences were equally distributed across early-, middle-, and late-myelinating regions. Overall, results within the CC support the retrogenesis model, although caution is needed when generalizing these results beyond the CC.
Author List
Stricker NH, Salat DH, Kuhn TP, Foley JM, Price JS, Westlye LT, Esterman MS, McGlinchey RE, Milberg WP, Leritz ECAuthor
Jenessa Price PhD Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Anisotropy
Brain
Cognitive Dysfunction
Corpus Callosum
Diffusion Tensor Imaging
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Myelin Sheath
Neuropsychological Tests
White Matter
