Portal vein ligation accelerates tumor growth in ligated, but not contralateral lobes. World J Gastroenterol 2010 Aug 14;16(30):3816-26
Date
08/11/2010Pubmed ID
20698045Pubmed Central ID
PMC2921094DOI
10.3748/wjg.v16.i30.3816Scopus ID
2-s2.0-77955767741 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
AIM: To investigate the mechanisms of liver growth and atrophy after portal vein ligation (PVL) and its effects on tumor growth.
METHODS: Mice were subjected to PVL, partial hepatectomy, or sham surgery. The morphological alterations, activation of transcription factors, and expression of cytokines and growth factors involved in liver regeneration were evaluated. In a separate set of experiments, murine colorectal carcinoma cells were injected via the portal vein and the effect of each operation on liver tumor growth was studied.
RESULTS: Liver regeneration after PVL and partial hepatectomy were very similar. In ligated lobes, various cytokines, transcription factors and regulatory factors were significantly upregulated compared to non-ligated lobes after PVL. Atrophy in ligated lobes was a result of early necrosis followed by later apoptosis. Tumor growth was significantly accelerated in ligated compared to non-ligated lobes.
CONCLUSION: Tumor growth was accelerated in ligated liver lobes and appeared to be a result of increased growth factor expression.
Author List
Sakai N, Clarke CN, Schuster R, Blanchard J, Tevar AD, Edwards MJ, Lentsch ABAuthor
Callisia N. Clarke MD Chief, Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApoptosis
Atrophy
Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms
Cytokines
Hepatectomy
Intercellular Signaling Peptides and Proteins
Ligation
Liver
Liver Neoplasms
Liver Regeneration
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Portal Vein
Signal Transduction
Time Factors
Tumor Burden
