Faculty Collaboration Database

CXC chemokines play a critical role in liver injury, recovery, and regeneration. Am J Surg 2009 Sep;198(3):415-9

Date

09/01/2009

Pubmed ID

19716886

Pubmed Central ID

PMC2736150

DOI

10.1016/j.amjsurg.2009.01.025

Scopus ID

2-s2.0-69249119868 (requires institutional sign-in at Scopus site)   47 Citations

Abstract

BACKGROUND: Hepatic ischemia/reperfusion (I/R) injury is a principal consideration of trauma, resectional liver surgery, and transplantation. Despite improvements in supportive care, hepatic I/R injury continues to negatively impact patient outcomes because of significant tissue damage and organ dysfunction. CXC chemokines have been implicated as key mediators in the deleterious inflammatory cascade after hepatic I/R and also as important, beneficial regulators of liver recovery and regeneration. As such, their potential to mediate both beneficial and detrimental effects on hepatocytes makes them a key target for therapy. Herein, we provide a review of the inflammatory mechanisms of hepatic I/R injury, with a focus on the divergent functions of CXC chemokines in this response compared with other liver insults, and offer an explanation of this apparent paradox.

DATA SOURCES: MEDLINE and PubMed.

CONCLUSIONS: CXC chemokines are key mediators of both the inflammatory response to hepatic I/R as well as the recovery from this injury. Their contrasting functions in the regeneration of liver mass after an ischemic insult indicates that therapeutic manipulation of these mediator pathways should differ depending on the surgical milieu.

Author List

Clarke CN, Kuboki S, Tevar A, Lentsch AB, Edwards M

Author

Callisia N. Clarke MD Chief, Associate Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Chemokines, CXC
Humans
Inflammation Mediators
Ischemia
Liver Regeneration
Recovery of Function
Reperfusion Injury
Signal Transduction