Faculty Collaboration Database

HTLV-III serology in hemophilia: relationship with immunologic abnormalities. J Pediatr 1986 Apr;108(4):511-6

Date

04/01/1986

Pubmed ID

3083075

DOI

10.1016/s0022-3476(86)80824-1

Scopus ID

2-s2.0-0022619581 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

We investigated the relationship of the presence of antibodies to HTLV-III and immunologic abnormalities in patients with hemophilia. Serum antibodies to HTLV-III were analyzed by ELISA assay, immunoprecipitation of labeled cell extracts, and immunoprecipitation of purified HTLV-III p24. Thirty-four (61%) of the total group (n = 56) had antibody to HTLV-III; 34 (76%) of 45 patients given commercial factor VIII preparations were seropositive, compared with none of 11 patients treated exclusively with cryoprecipitate obtained from volunteer blood donors. Of patients who were seropositive for HTLV-III antibody, 94% had abnormal T4/T8 ratios, and 33% of those whose serum was antibody negative had abnormal T4/T8 ratios; five patients, each antibody positive, have lymphadenopathy syndrome. Sequential studies in a subset of patients indicate that there is a changing pattern of antibody production to HTLV-III antigens after seroconversion.

Author List

Gill JC, Menitove JE, Anderson PR, Casper JT, Devare SG, Wood C, Adair S, Casey J, Scheffel C, Montgomery RR

Author

Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acquired Immunodeficiency Syndrome
Antibodies, Viral
Antibody Formation
Cells, Cultured
Cryoglobulins
Drug Contamination
Enzyme-Linked Immunosorbent Assay
Factor VIII
HIV Antibodies
Hemophilia A
Humans
Iodine Radioisotopes
Leukocyte Count
Male
Platelet Count
T-Lymphocytes