Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. Immunogenetics 2017 Mar;69(3):193-198
Date
11/01/2016Pubmed ID
27796442Pubmed Central ID
PMC5335865DOI
10.1007/s00251-016-0957-3Scopus ID
2-s2.0-84992740822 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Type 1 diabetes (T1D) results from complex interactions between genetic and environmental factors. The nonobese diabetic (NOD) mouse develops spontaneous T1D and has been used extensively to study the genetic control of this disease. T1D is suppressed in NOD mice congenic for the C57BL/10 (B10)-derived Idd9 resistance region on chromosome 4. Previous studies conducted by other investigators have identified four subregions (Idd9.1, Idd9.2, Idd9.3, and Idd9.4) where B10-derived genes suppress T1D development in NOD mice. We independently generated and characterized six congenic strains containing B10-derived intervals that partially overlap with the Idd9.1 and Idd9.4 regions. T1D incidence studies have revealed a new B10-derived resistance region proximal to Idd9.1. Our results also indicated that a B10-derived gene(s) within the Idd9.4 region suppressed the diabetogenic activity of CD4 T cells and promoted CD103 expression on regulatory T cells indicative of an activated phenotype. In addition, we suggest the presence of a B10-derived susceptibility gene(s) in the Idd9.1/Idd9.4 region. These results provide additional information to improve our understanding of the complex genetic control by the Idd9 region.
Author List
Lin B, Ciecko AE, MacKinney E, Serreze DV, Chen YGAuthor
Yi-Guang Chen PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsChromosome Mapping
Diabetes Mellitus, Type 1
Genetic Loci
Genetic Predisposition to Disease
Mice
Mice, Congenic
Mice, Inbred C57BL
Mice, Inbred NOD
Receptors, Tumor Necrosis Factor
T-Lymphocytes, Regulatory
