Medical College of Wisconsin
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Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. J Cardiovasc Transl Res 2017 Jun;10(3):295-304

Date

12/30/2016

Pubmed ID

28032312

Pubmed Central ID

PMC5937699

DOI

10.1007/s12265-016-9723-z

Scopus ID

2-s2.0-85007413634   5 Citations

Abstract

Heart failure with preserved left ventricular ejection fraction (HFpEF) has emerged as one of the largest unmet needs in cardiovascular medicine. HFpEF is increasing in prevalence and causes significant morbidity, mortality, and health care resource utilization. Patients have multiple co-morbidities which contribute to the disease complexity. To date, no effective treatment for HFpEF has been identified. The paucity of cardiac biopsies from this patient population and the absence of well-accepted animal models limit our understanding of the underlying molecular mechanisms of HFpEF. In this review, we discuss combining state-of-the-art technologies of microRNA profiling and human induced pluripotent cell-derived cardiomyocytes (iPSC-CMs) in order to uncover novel molecular pathways that may contribute to the development of HFpEF. Here, we focus the advantages and limitations of microRNA profiling and iPSC-CMs as a disease model system to discover molecular mechanisms in HFpEF.

Author List

Kriegel AJ, Gartz M, Afzal MZ, de Lange WJ, Ralphe JC, Strande JL

Author

Alison J. Kriegel PhD Associate Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cell Line
Gene Expression Regulation
Heart Failure
Humans
Induced Pluripotent Stem Cells
MicroRNAs
Myocytes, Cardiac
Phenotype
Signal Transduction
Stroke Volume
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d