Inhibitory effects of maesanin and analogs on arachidonic acid metabolizing enzymes. Planta Med 2001 Jun;67(4):360-1
Date
07/19/2001Pubmed ID
11458456DOI
10.1055/s-2001-14316Scopus ID
2-s2.0-0034955366 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
The substituted 1,4-benzoquinone, maesanin (1), is a potent 5-lipoxygenase (5-LO) inhibitor present in the fruit of Maesa lanceolata Forssk. Thirteen natural, synthetic, semisynthetic, and microbially transformed analogs of 1 were tested for their in vitro inhibition of 5-lipoxygenase (5-LO) and cyclooxygenase-1 (COX-1). Maesanin was the most active 5-LO inhibitor. All other analogs were inactive or less active than the natural products as 5-LO inhibitors. None of the tested compounds was strongly active in the COX-1 inhibition assay.
Author List
Abourashed EA, Muhammad I, Resch M, Bauer R, el-Feraly FS, Hufford CDAuthor
Ehab A. Abourashed PhD Professor in the School of Pharmacy Administration department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArachidonate 5-Lipoxygenase
Arachidonic Acids
Benzoquinones
Cyclooxygenase 1
Dinoprostone
Fruit
Isoenzymes
Leukocytes
Lipoxygenase Inhibitors
Male
Molecular Structure
Plants, Medicinal
Prostaglandin-Endoperoxide Synthases
Seminal Vesicles
Sheep
Swine
