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2-Hydroxy-5-(ethanolamino)-3-(10'-Z-pentadecenyl)-1,4-benzoquinone, new microbial phase II metabolite of maesanin. Chem Pharm Bull (Tokyo) 2000 Jan;48(1):45-7

Date

03/08/2000

Pubmed ID

10705473

DOI

10.1248/cpb.48.45

Scopus ID

2-s2.0-0033978179 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

The use of microbial models for biotransformation of the natural benzoquinone, maesanin (1), resulted in the isolation of an ethanolamine conjugate (5) from the culture broth of Debaryomyces polymorphus ATCC 20280. Metabolite 5 was characterized as 2-hydroxy-5-(ethanolamino)-3-(10'-Z-pentadecenyl)-1,4-benzoq uinone. The production of 5 represents a new type of phase II conjugation reaction in microbial systems. The results of preliminary mammalian metabolism of 1 in rats were inconclusive.

Author List

Abourashed EA, el-Feraly FS, Khan IA, Hufford CD

Author

Ehab A. Abourashed PhD Professor in the School of Pharmacy Administration department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acetylation
Animals
Benzoquinones
Biotransformation
Chromatography, High Pressure Liquid
Magnetic Resonance Spectroscopy
Male
Plants, Medicinal
Rats
Rats, Wistar
Saccharomycetales