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Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 2004 May;11(9):1135-46

Date

05/12/2004

Pubmed ID

15134511

DOI

10.2174/0929867043365387

Scopus ID

2-s2.0-2342544918   361 Citations

Abstract

alpha-Lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes. Aside from its enzymatic role, in vitro and in vivo studies suggest that LA also acts as a powerful micronutrient with diverse pharmacologic and antioxidant properties. Pharmacologically, LA improves glycemic control, polyneuropathies associated with diabetes mellitus, and effectively mitigates toxicities associated with heavy metal poisoning. As an antioxidant, LA directly terminates free radicals, chelates transition metal ions (e.g. iron and copper), increases cytosolic glutathione and vitamin C levels and prevents toxicities associated with their loss. These diverse actions suggest that LA acts by multiple mechanisms both physiologically and pharmacologically, many of which are only now being explored. Herein, we review the known biochemical properties of LA with particular reference to how LA may be an effective agent to ameliorate certain pathophysiologies of many chronic diseases.

Author List

Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM

Author

Michael E. Widlansky MD Associate Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Antioxidants
Chelation Therapy
Chronic Disease
Coenzymes
Diabetic Neuropathies
Free Radical Scavengers
Heavy Metal Poisoning, Nervous System
Humans
Metals, Heavy
Oxidative Stress
Reactive Nitrogen Species
Reactive Oxygen Species
Signal Transduction
Thioctic Acid
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d