Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.). Phytochem Rev 2016 Dec;15(6):1035-1056
Date
01/14/2017Pubmed ID
28082856Pubmed Central ID
PMC5222521DOI
10.1007/s11101-016-9469-xScopus ID
2-s2.0-84966525966 (requires institutional sign-in at Scopus site) 86 CitationsAbstract
Nutmeg is a valued kitchen spice that has been used for centuries all over the world. In addition to its use in flavoring foods and beverages, nutmeg has been used in traditional remedies for stomach and kidney disorders. The antioxidant, antimicrobial and central nervous system effects of nutmeg have also been reported in literature. Nutmeg is a rich source of fixed and essential oil, triterpenes, and various types of phenolic compounds. Many of the secondary metabolites of nutmeg exhibit biological activities that may support its use in traditional medicine. This article provides an overview of the chemistry of secondary metabolites isolated from nutmeg kernel and mace including common methods for analysis of extracts and pure compounds as well as recent approaches towards total synthesis of some of the major constituents. A summary of the most significant pharmacological investigations of potential drug leads isolated from nutmeg and reported in the last decade is also included.
Author List
Abourashed EA, El-Alfy ATAuthors
Ehab A. Abourashed PhD Professor in the School of Pharmacy Administration department at Medical College of WisconsinAbir El-Alfy PhD Assistant Dean, Professor in the School of Pharmacy Administration department at Medical College of Wisconsin