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Estimates of nasal airflow at the nasal cycle mid-point improve the correlation between objective and subjective measures of nasal patency. Respir Physiol Neurobiol 2017 04;238:23-32



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INTRODUCTION: The nasal cycle represents a significant challenge when comparing pre- and post-surgery objective measures of nasal airflow.

METHODS: Computational fluid dynamics (CFD) simulations of nasal airflow were conducted in 12 nasal airway obstruction patients showing significant nasal cycling between pre- and post-surgery computed tomography scans. To correct for the nasal cycle, mid-cycle models were created virtually. Subjective scores of nasal patency were obtained via the Nasal Obstruction Symptom Evaluation (NOSE) and unilateral visual analog scale (VAS).

RESULTS: The correlation between objective and subjective measures of nasal patency increased after correcting for the nasal cycle. In contrast to biophysical variables in individual patients, cohort averages were not significantly affected by the nasal cycle correction.

CONCLUSIONS: The ability to correct for the confounding effect of the nasal cycle is a key element that future virtual surgery planning software for nasal airway obstruction will need to account for when using anatomic models based on single instantaneous imaging.

Author List

Gaberino C, Rhee JS, Garcia GJ


Guilherme Garcia PhD Assistant Professor in the Biomedical Engineering department at Medical College of Wisconsin
John S. Rhee MD Chair, Professor in the Otolaryngology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Airway Resistance
Computational Biology
Computer Simulation
Imaging, Three-Dimensional
Minimally Invasive Surgical Procedures
Models, Biological
Nasal Mucosa
Nasal Obstruction
Pulmonary Ventilation
Statistics as Topic
Tomography Scanners, X-Ray Computed
Treatment Outcome
Visual Analog Scale
jenkins-FCD Prod-467 7c8a156729bba74d775d9c546792cde315827259