The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension. Curr Hypertens Rep 2017 Apr;19(4):27
Date
03/21/2017Pubmed ID
28316052Pubmed Central ID
PMC5773096DOI
10.1007/s11906-017-0721-6Scopus ID
2-s2.0-85015782153 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
PURPOSE OF REVIEW: The influence of gut bacteria upon host physiology is increasingly recognized, but mechanistic links are lacking. Diseases of energetic imbalance such as obesity and diabetes represent major risk factors for cardiovascular diseases such as hypertension. Thus, here, we review current mechanistic contributions of the gut microbiota to host energetics.
RECENT FINDINGS: Gut bacteria generate a multitude of small molecules which can signal to host tissues within and beyond the gastrointestinal tract to influence host physiology, and gut bacteria can also influence host digestive efficiency by altering the bioavailability of polysaccharides, yet the quantitative energetic effects of these processes remain unclear. Recently, our team has demonstrated that gut bacteria constitute a major anaerobic thermogenic biomass, which can quantitatively account for obesity. Quantitative understanding of the mechanisms by which gut bacteria influence energy homeostasis may ultimately inform the relationship between gut bacteria and cardiovascular dysfunction.
Author List
Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JRAuthors
Samantha N. Atkinson PhD Bioinformatics Analyst III in the Microbiology and Immunology department at Medical College of WisconsinJustin L. Grobe PhD Professor in the Physiology department at Medical College of Wisconsin
John Kirby PhD Chair, Center Associate Director, Professor in the Microbiology and Immunology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsCardiovascular Diseases
Gastrointestinal Microbiome
Gastrointestinal Tract
Homeostasis
Humans
Hypertension
Obesity
