Faculty Collaboration Database

Off-resonance based assessment of metallic wear debris near total hip arthroplasty. Magn Reson Med 2018 Mar;79(3):1628-1637

Date

06/24/2017

Pubmed ID

28643347

Pubmed Central ID

PMC5741538

DOI

10.1002/mrm.26807

Scopus ID

2-s2.0-85021256752 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

PURPOSE: The presence of metallic debris near total hip arthroplasty can have a significant impact on longitudinal patient management. Methods for magnetic resonance imaging-based quantification of metallic debris near painful total hip replacements are described and applied to cohorts of symptomatic and control subject cases.

METHODS: A combination of metal artifact reduction, off-resonance mapping, off-resonance background removal, and spatial clustering methods are utilized to quantify off-resonance signatures in cases of suspected metallosis. These methods are applied to a cohort of symptomatic hip arthroplasties composed of cobalt-chromium alloys. Magnetostatic simulations and theoretical principles are used to illuminate the potential sources of the measured off-resonance effects. Reported metrics from histological tissue assays extracted during surgical revision procedures are also correlated with the proposed magnetic resonance imaging-based quantification results.

RESULTS: The presented methods identified quantifiable metallosis signatures in more than 70% of the symptomatic and none of the control cases. Preliminary correlations of the MR data with direct histological evaluation of retrieved tissue samples indicate that the observed off-resonance effect may be related to tissue necrosis.

CONCLUSIONS: Magnetostatic simulations, theoretical principles, and preliminary histological trends suggest that disassociated cobalt is the source of the observed off-resonance signature. Magn Reson Med 79:1628-1637, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Author List

Koch KM, Koff MF, Bauer TW, Shah PH, Nencka AS, Sivaram Kaushik S, Potter HG

Authors

Kevin M. Koch PhD Center Director, Professor in the Radiology department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Arthroplasty, Replacement, Hip
Chromium Alloys
Cohort Studies
Computer Simulation
Female
Hip Joint
Hip Prosthesis
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Prosthesis Failure