Faculty Collaboration Database

Role of adaptor protein p66Shc in renal pathologies. Am J Physiol Renal Physiol 2018 Feb 01;314(2):F143-F153

Date

10/06/2017

Pubmed ID

28978535

Pubmed Central ID

PMC5866456

DOI

10.1152/ajprenal.00414.2017

Scopus ID

2-s2.0-85043593186 (requires institutional sign-in at Scopus site)   24 Citations

Abstract

p66Shc is one of the three adaptor proteins encoded by the Shc1 gene, which are expressed in many organs, including the kidney. Recent studies shed new light on several key questions concerning the signaling mechanisms mediated by p66Shc. The central goal of this review article is to summarize recent findings on p66Shc and the role it plays in kidney physiology and pathology. This article provides a review of the various mechanisms whereby p66Shc has been shown to function within the kidney through a wide range of actions. The mitochondrial and cytoplasmic signaling of p66Shc, as it relates to production of reactive oxygen species (ROS) and renal pathologies, is further discussed.

Author List

Wright KD, Staruschenko A, Sorokin A

Author

Andrey Sorokin PhD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Apoptosis
Humans
Kidney
Kidney Diseases
Mitochondria
Oxidative Stress
Reactive Oxygen Species
Signal Transduction
Src Homology 2 Domain-Containing, Transforming Protein 1