Faculty Collaboration Database

A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference. Neurosci Lett 2011 Nov 07;505(1):10-3

Date

08/11/2011

Pubmed ID

21827831

Pubmed Central ID

PMC3213641

DOI

10.1016/j.neulet.2011.07.036

Scopus ID

2-s2.0-82455167912 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

This study was designed to determine whether a 5-HT(2C) receptor antagonist could induce a conditioned place preference indicative of reward and/or abuse potential. Here, we present the first evidence that a selective 5-HT(2C) receptor antagonist, 6-chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide hydrochloride (CEPC), can potentiate a low dose (0.5 mg/kg) amphetamine-induced positive conditioned place preference (CPP). CEPC did not produce any CPP given alone at doses of either 2.0 or 4.0 mg/kg, whereas low dose amphetamine alone produced only a slight, but statistically nonsignificant, place preference. These studies suggest that 5-HT(2C) receptor antagonists can indirectly potentiate the rewarding effects of amphetamine, and perhaps other psychostimulants. If the results can be translated to man, putative 5-HT(2C) receptor antagonist treatments for anxiety or depression may enhance or potentiate the rewarding effects of drugs of abuse such as amphetamine, which release dopamine.

Author List

McCorvy JD, Harland AA, Maglathlin R, Nichols DE

Author

John McCorvy PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aminopyridines
Amphetamine
Animals
Behavior, Animal
Central Nervous System Stimulants
Conditioning, Operant
Dose-Response Relationship, Drug
Indoles
Male
Rats
Rats, Sprague-Dawley
Serotonin 5-HT2 Receptor Agonists
Serotonin 5-HT2 Receptor Antagonists