Medical College of Wisconsin
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John McCorvy PhD

John McCorvy PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center
Member of the Neuroscience Research Center


I am willing to collaborate on research projects.


Research Experience

  • Antipsychotic Agents
  • Binding Sites
  • Central Nervous System Stimulants
  • Crystallography, X-Ray
  • Dopamine Agonists
  • Drug Design
  • Drug Discovery
  • Hallucinogens
  • Kinetics
  • Ligands
  • Lysergic Acid Diethylamide
  • Models, Molecular
  • Molecular Structure
  • Mutation
  • Piperazines
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Secondary
  • Receptor, Melatonin, MT1
  • Receptor, Serotonin, 5-HT2B
  • Receptor, Serotonin, 5-HT2C
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Receptors, G-Protein-Coupled
  • Schizophrenia
  • Serotonin 5-HT2 Receptor Agonists
  • Signal Transduction
  • Structure-Activity Relationship
  • beta-Arrestins
  • Publications (46)

  • TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. (Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT) Nat Chem Biol 2020 08;16(8):841-849 PMID: 32367019 05/06/2020       4 Citations
  • Structure-based discovery of potent and selective melatonin receptor agonists. (Patel N, Huang XP, Grandner JM, Johansson LC, Stauch B, McCorvy JD, Liu Y, Roth B, Katritch V) Elife 2020 Mar 02;9 PMID: 32118583 PMCID: PMC7080406 03/03/2020       2 Citations
  • Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin. (Sherwood AM, Halberstadt AL, Klein AK, McCorvy JD, Kaylo KW, Kargbo RB, Meisenheimer P) J Nat Prod 2020 02 28;83(2):461-467 PMID: 32077284 02/23/2020       6 Citations
  • Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. (Stein RM, Kang HJ, McCorvy JD, Glatfelter GC, Jones AJ, Che T, Slocum S, Huang XP, Savych O, Moroz YS, Stauch B, Johansson LC, Cherezov V, Kenakin T, Irwin JJ, Shoichet BK, Roth BL, Dubocovich ML) Nature 2020 03;579(7800):609-614 PMID: 32040955 PMCID: PMC7134359 02/11/2020       10 Citations
  • Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). (Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD) Neuropharmacology 2020 08 01;172:107856 PMID: 31756337 11/23/2019       6 Citations
  • Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. (Sahu BS, Rodriguez P, Nguyen ME, Han R, Cero C, Razzoli M, Piaggi P, Laskowski LJ, Pavlicev M, Muglia L, Mahata SK, O'Grady S, McCorvy JD, Baier LJ, Sham YY, Bartolomucci A) Cell Rep 2019 Sep 03;28(10):2567-2580.e6 PMID: 31484069 PMCID: PMC6753381 09/05/2019       3 Citations
  • Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism. (Zhang G, McCorvy JD, Shen S, Cheng J, Roth BL, Kozikowski AP) Eur J Med Chem 2019 Nov 15;182:111626 PMID: 31445232 PMCID: PMC6815260 08/25/2019       2 Citations
  • Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. (Martini ML, Ray C, Yu X, Liu J, Pogorelov VM, Wetsel WC, Huang XP, McCorvy JD, Caron MG, Jin J) ACS Chem Neurosci 2019 09 18;10(9):4160-4182 PMID: 31387346 PMCID: PMC6785188 08/08/2019       4 Citations
  • Structural basis of ligand recognition at the human MT1 melatonin receptor. (Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V) Nature 2019 05;569(7755):284-288 PMID: 31019306 PMCID: PMC6696938 04/26/2019       39 Citations
  • XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity. (Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V) Nature 2019 05;569(7755):289-292 PMID: 31019305 PMCID: PMC6589158 04/26/2019       33 Citations
  • D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. (Shen Y, McCorvy JD, Martini ML, Rodriguiz RM, Pogorelov VM, Ward KM, Wetsel WC, Liu J, Roth BL, Jin J) J Med Chem 2019 05 09;62(9):4755-4771 PMID: 30964661 PMCID: PMC6509010 04/10/2019       3 Citations
  • Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. (Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs N, McCorvy JD, Caron MG, Roth BL, Jin J) J Med Chem 2019 04 11;62(7):3753-3772 PMID: 30875219 PMCID: PMC6688508 03/16/2019       3 Citations
  • Structural determinants of 5-HT2B receptor activation and biased agonism. (McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL) Nat Struct Mol Biol 2018 09;25(9):787-796 PMID: 30127358 PMCID: PMC6237183 08/22/2018       28 Citations
  • Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. (Tan L, Yan W, McCorvy JD, Cheng J) J Med Chem 2018 11 21;61(22):9841-9878 PMID: 29939744 06/26/2018       29 Citations
  • High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. (Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, Hanson MA, Liu ZJ, Wang MW, Stevens RC, Shui W) Chem Sci 2018 Mar 28;9(12):3192-3199 PMID: 29732102 PMCID: PMC5916221 05/08/2018    
  • 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. (Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ) Cell 2018 02 08;172(4):719-730.e14 PMID: 29398112 PMCID: PMC6309861 02/06/2018       76 Citations
  • Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. (Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL) Cell 2018 01 11;172(1-2):55-67.e15 PMID: 29307491 PMCID: PMC5802374 01/09/2018       107 Citations
  • Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. (McCorvy JD, Butler KV, Kelly B, Rechsteiner K, Karpiak J, Betz RM, Kormos BL, Shoichet BK, Dror RO, Jin J, Roth BL) Nat Chem Biol 2018 02;14(2):126-134 PMID: 29227473 PMCID: PMC5771956 12/12/2017       47 Citations
  • The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. (Chan JD, Cupit PM, Gunaratne GS, McCorvy JD, Yang Y, Stoltz K, Webb TR, Dosa PI, Roth BL, Abagyan R, Cunningham C, Marchant JS) Nat Commun 2017 12 05;8(1):1910 PMID: 29208933 PMCID: PMC5716991 SCOPUS ID: 2-s2.0-85037138864 12/07/2017       38 Citations
  • D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. (Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL) Science 2017 10 20;358(6361):381-386 PMID: 29051383 PMCID: PMC5856174 10/21/2017       75 Citations
  • Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. (Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP) J Med Chem 2017 07 27;60(14):6273-6288 PMID: 28657744 PMCID: PMC7374938 06/29/2017       12 Citations
  • Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775). (Brandt SD, Kavanagh PV, Twamley B, Westphal F, Elliott SP, Wallach J, Stratford A, Klein LM, McCorvy JD, Nichols DE, Halberstadt AL) Drug Test Anal 2018 Feb;10(2):310-322 PMID: 28585392 PMCID: PMC6230476 06/07/2017       17 Citations
  • Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation. (Hoehn RD, Nichols DE, McCorvy JD, Neven H, Kais S) Proc Natl Acad Sci U S A 2017 05 30;114(22):5595-5600 PMID: 28500275 PMCID: PMC5465905 05/14/2017       6 Citations
  • Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist. (Jensen AA, McCorvy JD, Leth-Petersen S, Bundgaard C, Liebscher G, Kenakin TP, Bräuner-Osborne H, Kehler J, Kristensen JL) J Pharmacol Exp Ther 2017 06;361(3):441-453 PMID: 28360333 04/01/2017       13 Citations
  • In silico design of novel probes for the atypical opioid receptor MRGPRX2. (Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL) Nat Chem Biol 2017 05;13(5):529-536 PMID: 28288109 PMCID: PMC5391270 03/14/2017       88 Citations
  • Crystal Structure of an LSD-Bound Human Serotonin Receptor. (Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL) Cell 2017 01 26;168(3):377-389.e12 PMID: 28129538 PMCID: PMC5289311 01/28/2017       134 Citations
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. (Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG) Proc Natl Acad Sci U S A 2016 12 13;113(50):E8178-E8186 PMID: 27911814 PMCID: PMC5167191 12/03/2016       63 Citations
  • Psilocybin for depression and anxiety associated with life-threatening illnesses. (McCorvy JD, Olsen RH, Roth BL) J Psychopharmacol 2016 12;30(12):1209-1210 PMID: 27909171 12/03/2016    
  • Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists. (Chen X, McCorvy JD, Fischer MG, Butler KV, Shen Y, Roth BL, Jin J) J Med Chem 2016 12 08;59(23):10601-10618 PMID: 27805392 PMCID: PMC5148701 11/03/2016       30 Citations
  • Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists. (Cheng J, McCorvy JD, Giguere PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP) J Med Chem 2016 11 10;59(21):9866-9880 PMID: 27726356 10/12/2016       18 Citations
  • Structure-based discovery of opioid analgesics with reduced side effects. (Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK) Nature 2016 09 08;537(7619):185-190 PMID: 27533032 PMCID: PMC5161585 08/18/2016       389 Citations
  • A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. (Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS) PLoS Pathog 2016 05;12(5):e1005651 PMID: 27187180 PMCID: PMC4871480 SCOPUS ID: 2-s2.0-84973334825 05/18/2016       23 Citations
  • In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. (Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL) PLoS One 2016;11(3):e0150602 PMID: 26963248 PMCID: PMC4786259 03/11/2016       12 Citations
  • Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. (Cheng J, Giguere PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP) J Med Chem 2016 Jan 28;59(2):578-91 PMID: 26704965 12/26/2015       15 Citations
  • PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. (Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL) Nat Struct Mol Biol 2015 May;22(5):362-9 PMID: 25895059 PMCID: PMC4424118 04/22/2015       184 Citations
  • Structure and function of serotonin G protein-coupled receptors. (McCorvy JD, Roth BL) Pharmacol Ther 2015 Jun;150:129-42 PMID: 25601315 PMCID: PMC4414735 01/21/2015       128 Citations
  • Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. (Hansen M, Jacobsen SE, Plunkett S, Liebscher GE, McCorvy JD, Bräuner-Osborne H, Kristensen JL) Bioorg Med Chem 2015 Jul 15;23(14):3933-7 PMID: 25583099 01/15/2015       12 Citations
  • Structural features for functional selectivity at serotonin receptors. (Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC) Science 2013 May 03;340(6132):615-9 PMID: 23519215 PMCID: PMC3644390 03/23/2013    
  • Structural basis for molecular recognition at serotonin receptors. (Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC, Xu HE) Science 2013 May 03;340(6132):610-4 PMID: 23519210 PMCID: PMC3644373 03/23/2013    
  • Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. (Juncosa JI Jr, Hansen M, Bonner LA, Cueva JP, Maglathlin R, McCorvy JD, Marona-Lewicka D, Lill MA, Nichols DE) ACS Chem Neurosci 2013 Jan 16;4(1):96-109 PMID: 23336049 PMCID: PMC3547484 01/22/2013       30 Citations
  • trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. (Pigott A, Frescas S, McCorvy JD, Huang XP, Roth BL, Nichols DE) Beilstein J Org Chem 2012;8:1705-9 PMID: 23209503 PMCID: PMC3511003 12/05/2012    
  • Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. (Clark AH, McCorvy JD, Conley JM, Williams WK, Bekkam M, Watts VJ, Nichols DE) Bioorg Med Chem 2012 Nov 01;20(21):6366-74 PMID: 23018094 PMCID: PMC3505999 09/29/2012       6 Citations
  • Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease. (McCorvy JD, Watts VJ, Nichols DE) Psychopharmacology (Berl) 2012 Jul;222(1):81-7 PMID: 22222862 01/10/2012       5 Citations
  • Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. (Clark AH, McCorvy JD, Watts VJ, Nichols DE) Bioorg Med Chem 2011 Sep 15;19(18):5420-31 PMID: 21862338 PMCID: PMC3171562 08/25/2011       8 Citations
  • A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference. (McCorvy JD, Harland AA, Maglathlin R, Nichols DE) Neurosci Lett 2011 Nov 07;505(1):10-3 PMID: 21827831 PMCID: PMC3213641 08/11/2011       5 Citations
  • Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. (Przybyla JA, Cueva JP, Chemel BR, Hsu KJ, Riese DJ 2nd, McCorvy JD, Chester JA, Nichols DE, Watts VJ) Eur Neuropsychopharmacol 2009 Feb;19(2):138-46 PMID: 19028082 PMCID: PMC2636714 11/26/2008       13 Citations
  • Last update: 10/13/2020
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