Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists. Free Radic Res 2006 Jul;40(7):741-52
Date
09/21/2006Pubmed ID
16984001DOI
10.1080/10715760600690329Scopus ID
2-s2.0-37349088295 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
It is claimed that novel beta-adrenolytic drugs possess superior antioxidant properties as compared to classical selective or non-selective beta-adrenoceptor antagonists. Here we tested this notion by analyzing radical scavenging properties of selected beta-adrenolytic drugs and their ability to release nitric oxide in biological preparations. Selective beta1-adrenolytics such as nebivolol, atenolol, metoprolol and non-selective beta-adrenolytics with alpha1-receptor blocking properties such as carvedilol and labetalol were chosen for analysis. NO-releasing properties of nebivolol and carvedilol distinguished third generation beta-adrenolytics from their older counterparts while the reactivity towards hydroxyl and peroxyl radicals discerns only carvedilol but not nebivolol. Thus, superior clinical efficacy of third generation beta-adrenolytics may be related to their ability to release NO rather then to their direct antioxidant properties.
Author List
Szajerski P, Zielonka J, Sikora A, Adamus J, Marcinek A, Gebicki J, Kozlovski VI, Drelicharz L, Chłopicki SAuthor
Jacek M. Zielonka PhD Assistant Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenergic beta-AntagonistsAnimals
Benzopyrans
Carbazoles
Coronary Circulation
Coronary Vessels
Endothelium, Vascular
Epoxy Compounds
Ethanolamines
Female
Free Radical Scavengers
Guinea Pigs
In Vitro Techniques
Male
Methylamines
Nebivolol
Nitric Oxide
Propanolamines
Pulse Radiolysis
Vasodilation
