Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science 2006 Apr 28;312(5773):577-9
Date
04/29/2006Pubmed ID
16645095DOI
10.1126/science.1124153Scopus ID
2-s2.0-33646250928 (requires institutional sign-in at Scopus site) 222 CitationsAbstract
We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.
Author List
Riehle MM, Markianos K, Niaré O, Xu J, Li J, Touré AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traoré SF, Vernick KDAuthor
Michelle M. Riehle PhD Assistant Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AllelesAnimals
Anopheles
Chromosome Mapping
Female
Genes, Insect
Genetic Linkage
Genetic Variation
Genome, Insect
Humans
Immunity, Innate
Insect Proteins
Insect Vectors
Malaria, Falciparum
Male
Mali
Oligonucleotide Array Sequence Analysis
Pedigree
Phenotype
Plasmodium berghei
Plasmodium falciparum
RNA Interference
