Medical College of Wisconsin
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Michelle M. Riehle PhD

Michelle M. Riehle PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Center for Immunology

Research Experience

  • Anopheles
  • Evolution, Molecular
  • Genetic Variation
  • Host-Parasite Interactions
  • Immunity, Innate
  • Insect Vectors
  • Malaria, Falciparum

    • Educational Expertise

  • Evolution, Molecular
  • Genetics
  • Microbiology

    • Publications (50)

  • Molecular characterization and genetic authentication assay for Anopheles 'hemocyte-like' cell lines 4a-3A and 4a-3B. (Eggleston H, Njoya K, Anderson CE, Holm I, Eiglmeier K, Liang J, Sharakhov IV, Vernick KD, Riehle MM) Parasit Vectors 2022 Dec 13;15(1):465 PMID: 36514125 PMCID: PMC9749150 SCOPUS ID: 2-s2.0-85143791043 12/14/2022    
  • Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium. (Bukhari T, Aimanianda V, Bischoff E, Brito-Fravallo E, Eiglmeier K, Riehle MM, Vernick KD, Mitri C) Sci Rep 2022 Apr 15;12(1):6315 PMID: 35428783 PMCID: PMC9012835 SCOPUS ID: 2-s2.0-85128387936 04/17/2022       4 Citations
  • Comprehensive Genomic Discovery of Non-Coding Transcriptional Enhancers in the African Malaria Vector Anopheles coluzzii. (Holm I, Nardini L, Pain A, Bischoff E, Anderson CE, Zongo S, Guelbeogo WM, Sagnon N, Gohl DM, Nowling RJ, Vernick KD, Riehle MM) Front Genet 2021;12:785934 PMID: 35082832 PMCID: PMC8784733 SCOPUS ID: 2-s2.0-85123364427 01/28/2022       2 Citations
  • Anopheles ecology, genetics and malaria transmission in northern Cambodia (Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B) Scientific Reports December 2021;11(1) SCOPUS ID: 2-s2.0-85102850695 12/01/2021       23 Citations
  • Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia (Scientific Reports, (2021), 11, 1, (6458), 10.1038/s41598-021-85628-1) (Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B) Scientific Reports December 2021;11(1) SCOPUS ID: 2-s2.0-85107408524 12/01/2021       1 Citation
  • Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia. (Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B) Sci Rep 2021 Jun 09;11(1):12553 PMID: 34108534 PMCID: PMC8190266 SCOPUS ID: 2-s2.0-85107408524 06/11/2021       1 Citation
  • Comprehensive Ecological and Geographic Characterization of Eukaryotic and Prokaryotic Microbiomes in African Anopheles. (Cuesta EB, Coulibaly B, Bukhari T, Eiglmeier K, Kone R, Coulibaly MB, Zongo S, Barry M, Gneme A, Guelbeogo WM, Beavogui AH, Traore SF, Sagnon N, Vernick KD, Riehle MM) Front Microbiol 2021;12:635772 PMID: 34054746 PMCID: PMC8153677 SCOPUS ID: 2-s2.0-85107059364 06/01/2021       6 Citations
  • Anopheles ecology, genetics and malaria transmission in northern Cambodia. (Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B) Sci Rep 2021 Mar 19;11(1):6458 PMID: 33742030 PMCID: PMC7979810 SCOPUS ID: 2-s2.0-85102850695 03/21/2021       23 Citations
  • Filtering the Junk: Assigning Function to the Mosquito Non-Coding Genome. (Farley EJ, Eggleston H, Riehle MM) Insects 2021 Feb 22;12(2) PMID: 33671692 PMCID: PMC7926655 SCOPUS ID: 2-s2.0-85102368307 03/07/2021       6 Citations
  • Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus (Grau-Bové X, Lucas E, Pipini D, Rippon E, van ‘t Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski DP, Donnelly MJ, Weetman D, Amaya-Romero JE, Ayala D, Battey CJ, Bejon P, Besansky NJ, Burt A, Cano J, Caputo B, Constant E, Costantini C, Coulibaly B, della Torre A, Diabaté A, Dinis J, Donnelly MJ, Drury E, Edouardo J, Elissa N, Essandoh J, Fontaine MC, Godfray CHJ, Hahn MW, Harding NJ, Henrichs C, Hubbart C, Isaacs AT, Jawara M, Jeffreys AE, Jyothi D, Kamali M, Kern AD, Clarkson CS, Lawniczak MKN, Le Goff G, Lucas ER, Malangone C, Mawejje HD, Mbogo C, Mead D, Midega J, Miles A, Nwakanma DC, O’Loughlin S, Pinto J, Riehle MM, Robert V, Rockett KA, Rohatgi KR, Rowlands K, Schrider DR, Sharakhov I, Simpson V, Stalker J, Troco AD, Vernick KD, Weetman D, Bradley J) PLoS Genetics 21 January 2021;17(1) SCOPUS ID: 2-s2.0-85099805834 01/21/2021       21 Citations
  • Discovery of Ongoing Selective Sweeps within Anopheles Mosquito Populations Using Deep Learning. (Xue AT, Schrider DR, Kern AD, Ag1000g Consortium) Mol Biol Evol 2021 Mar 09;38(3):1168-1183 PMID: 33022051 PMCID: PMC7947845 SCOPUS ID: 2-s2.0-85102911117 10/07/2020       15 Citations
  • Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii. (Anopheles gambiae 1000 Genomes Consortium) Genome Res 2020 Oct;30(10):1533-1546 PMID: 32989001 PMCID: PMC7605271 SCOPUS ID: 2-s2.0-85092682445 09/30/2020       45 Citations
  • Leucine-Rich Immune Factor APL1 Is Associated With Specific Modulation of Enteric Microbiome Taxa in the Asian Malaria Mosquito Anopheles stephensi. (Mitri C, Bischoff E, Belda Cuesta E, Volant S, Ghozlane A, Eiglmeier K, Holm I, Dieme C, Brito-Fravallo E, Guelbeogo WM, Sagnon N, Riehle MM, Vernick KD) Front Microbiol 2020;11:306 PMID: 32174902 PMCID: PMC7054466 SCOPUS ID: 2-s2.0-85082417635 03/17/2020       13 Citations
  • Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium. (Dieme C, Zmarlak NM, Brito-Fravallo E, Travaillé C, Pain A, Cherrier F, Genève C, Calvo-Alvarez E, Riehle MM, Vernick KD, Rotureau B, Mitri C) PLoS Negl Trop Dis 2020 Feb;14(2):e0008059 PMID: 32032359 PMCID: PMC7032731 SCOPUS ID: 2-s2.0-85081144453 02/08/2020       10 Citations
  • Gene copy number and function of the APL1 immune factor changed during Anopheles evolution. (Mitri C, Bischoff E, Eiglmeier K, Holm I, Dieme C, Brito-Fravallo E, Raz A, Zakeri S, Nejad MIK, Djadid ND, Vernick KD, Riehle MM) Parasit Vectors 2020 Jan 13;13(1):18 PMID: 31931885 PMCID: PMC6958605 SCOPUS ID: 2-s2.0-85077786231 01/15/2020       8 Citations
  • Influence of genetic polymorphism on transcriptional enhancer activity in the malaria vector Anopheles coluzzii. (Nardini L, Holm I, Pain A, Bischoff E, Gohl DM, Zongo S, Guelbeogo WM, Sagnon N, Vernick KD, Riehle MM) Sci Rep 2019 Oct 24;9(1):15275 PMID: 31649293 PMCID: PMC6813320 SCOPUS ID: 2-s2.0-85074074218 10/28/2019       10 Citations
  • Genetic diversity of the African malaria vector Anopheles gambiae. (Anopheles gambiae 1000 Genomes Consortium, Data analysis group, Partner working group, Sample collections—Angola:, Burkina Faso:, Cameroon:, Gabon:, Guinea:, Guinea-Bissau:, Kenya:, Uganda:, Crosses:, Sequencing and data production, Web application development, Project coordination) Nature 2017 Dec 07;552(7683):96-100 PMID: 29186111 PMCID: PMC6026373 SCOPUS ID: 2-s2.0-85038811995 12/01/2017       202 Citations
  • The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa. (Riehle MM, Bukhari T, Gneme A, Guelbeogo WM, Coulibaly B, Fofana A, Pain A, Bischoff E, Renaud F, Beavogui AH, Traore SF, Sagnon N, Vernick KD) Elife 2017 Jun 23;6 PMID: 28643631 PMCID: PMC5482571 SCOPUS ID: 2-s2.0-85021397890 06/24/2017       38 Citations
  • Preferential suppression of Anopheles gambiae host sequences allows detection of the mosquito eukaryotic microbiome. (Belda E, Coulibaly B, Fofana A, Beavogui AH, Traore SF, Gohl DM, Vernick KD, Riehle MM) Sci Rep 2017 Jun 12;7(1):3241 PMID: 28607435 PMCID: PMC5468309 SCOPUS ID: 2-s2.0-85020718351 06/14/2017       33 Citations
  • Correction: An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors. (Mitri C, Bischoff E, Takashima E, Williams M, Eiglmeier K, Pain A, Guelbeogo WM, Gneme A, Brito-Fravallo E, Holm I, Lavazec C, Sagnon N, Baxter RH, Riehle MM, Vernick KD) PLoS Pathog 2016 Aug;12(8):e1005836 PMID: 27518517 PMCID: PMC4982601 SCOPUS ID: 2-s2.0-85128483009 08/16/2016    
  • Malaria vector populations across ecological zones in Guinea Conakry and Mali, West Africa. (Coulibaly B, Kone R, Barry MS, Emerson B, Coulibaly MB, Niare O, Beavogui AH, Traore SF, Vernick KD, Riehle MM) Malar J 2016 Apr 08;15:191 PMID: 27059057 PMCID: PMC4826509 SCOPUS ID: 2-s2.0-84966415575 04/10/2016       21 Citations
  • Evolution of GOUNDRY, a cryptic subgroup of Anopheles gambiae s.l., and its impact on susceptibility to Plasmodium infection. (Crawford JE, Riehle MM, Markianos K, Bischoff E, Guelbeogo WM, Gneme A, Sagnon N, Vernick KD, Nielsen R, Lazzaro BP) Mol Ecol 2016 Apr;25(7):1494-510 PMID: 26846876 SCOPUS ID: 2-s2.0-84960921872 02/06/2016       13 Citations
  • Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso. (Markianos K, Bischoff E, Mitri C, Guelbeogo WM, Gneme A, Eiglmeier K, Holm I, Sagnon N, Vernick KD, Riehle MM) PLoS One 2016;11(1):e0145308 PMID: 26731649 PMCID: PMC4701492 SCOPUS ID: 2-s2.0-84953889084 01/06/2016       7 Citations
  • An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors. (Mitri C, Bischoff E, Takashima E, Williams M, Eiglmeier K, Pain A, Guelbeogo WM, Gneme A, Brito-Fravallo E, Holm I, Lavazec C, Sagnon N, Baxter RH, Riehle MM, Vernick KD) PLoS Pathog 2015 Dec;11(12):e1005306 PMID: 26633695 PMCID: PMC4669117 SCOPUS ID: 2-s2.0-84953266859 12/04/2015       17 Citations
  • Reticulate Speciation and Barriers to Introgression in the Anopheles gambiae Species Complex. (Crawford JE, Riehle MM, Guelbeogo WM, Gneme A, Sagnon N, Vernick KD, Nielsen R, Lazzaro BP) Genome Biol Evol 2015 Nov 28;7(11):3116-31 PMID: 26615027 PMCID: PMC4994751 SCOPUS ID: 2-s2.0-84957077006 11/29/2015       27 Citations
  • Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae. (Redmond SN, Eiglmeier K, Mitri C, Markianos K, Guelbeogo WM, Gneme A, Isaacs AT, Coulibaly B, Brito-Fravallo E, Maslen G, Mead D, Niare O, Traore SF, Sagnon N, Kwiatkowski D, Riehle MM, Vernick KD) BMC Genomics 2015 Oct 13;16:779 PMID: 26462916 PMCID: PMC4603968 SCOPUS ID: 2-s2.0-84945219062 10/16/2015       14 Citations
  • The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing. (Mitri C, Markianos K, Guelbeogo WM, Bischoff E, Gneme A, Eiglmeier K, Holm I, Sagnon N, Vernick KD, Riehle MM) Malar J 2015 Oct 06;14:391 PMID: 26445487 PMCID: PMC4596459 SCOPUS ID: 2-s2.0-84943228821 10/09/2015       31 Citations
  • Population genetics of Anopheles coluzzii immune pathways and genes. (Rottschaefer SM, Crawford JE, Riehle MM, Guelbeogo WM, Gneme A, Sagnon N, Vernick KD, Lazzaro BP) G3 (Bethesda) 2014 Dec 30;5(3):329-39 PMID: 25552603 PMCID: PMC4349087 SCOPUS ID: 2-s2.0-84924651120 01/02/2015       9 Citations
  • Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi. (Jiang X, Peery A, Hall AB, Sharma A, Chen XG, Waterhouse RM, Komissarov A, Riehle MM, Shouche Y, Sharakhova MV, Lawson D, Pakpour N, Arensburger P, Davidson VL, Eiglmeier K, Emrich S, George P, Kennedy RC, Mane SP, Maslen G, Oringanje C, Qi Y, Settlage R, Tojo M, Tubio JM, Unger MF, Wang B, Vernick KD, Ribeiro JM, James AA, Michel K, Riehle MA, Luckhart S, Sharakhov IV, Tu Z) Genome Biol 2014 Sep 23;15(9):459 PMID: 25244985 PMCID: PMC4195908 SCOPUS ID: 2-s2.0-84984941657 09/24/2014       86 Citations
  • Equivalent susceptibility of Anopheles gambiae M and S molecular forms and Anopheles arabiensis to Plasmodium falciparum infection in Burkina Faso. (Gnémé A, Guelbéogo WM, Riehle MM, Sanou A, Traoré A, Zongo S, Eiglmeier K, Kabré GB, Sagnon N, Vernick KD) Malar J 2013 Jun 14;12:204 PMID: 23764031 PMCID: PMC3687573 SCOPUS ID: 2-s2.0-84878894259 06/15/2013       28 Citations
  • Wild Anopheles funestus mosquito genotypes are permissive for infection with the rodent malaria parasite, Plasmodium berghei. (Xu J, Hillyer JF, Coulibaly B, Sacko M, Dao A, Niaré O, Riehle MM, Traoré SF, Vernick KD) PLoS One 2013;8(4):e61181 PMID: 23593423 PMCID: PMC3620233 SCOPUS ID: 2-s2.0-84875986633 04/18/2013       8 Citations
  • Plasmodium species occurrence, temporal distribution and interaction in a child-aged population in rural Burkina Faso. (Gnémé A, Guelbéogo WM, Riehle MM, Tiono AB, Diarra A, Kabré GB, Sagnon N, Vernick KD) Malar J 2013 Feb 19;12:67 PMID: 23421809 PMCID: PMC3583752 SCOPUS ID: 2-s2.0-84873975798 02/21/2013       37 Citations
  • No evidence for positive selection at two potential targets for malaria transmission-blocking vaccines in Anopheles gambiae s.s. (Crawford JE, Rottschaefer SM, Coulibaly B, Sacko M, Niaré O, Riehle MM, Traore SF, Vernick KD, Lazzaro BP) Infect Genet Evol 2013 Jun;16:87-92 PMID: 23357581 PMCID: PMC3763813 SCOPUS ID: 2-s2.0-84875262280 01/30/2013       3 Citations
  • Diverged alleles of the Anopheles gambiae leucine-rich repeat gene APL1A display distinct protective profiles against Plasmodium falciparum. (Holm I, Lavazec C, Garnier T, Mitri C, Riehle MM, Bischoff E, Brito-Fravallo E, Takashima E, Thiery I, Zettor A, Petres S, Bourgouin C, Vernick KD, Eiglmeier K) PLoS One 2012;7(12):e52684 PMID: 23285147 PMCID: PMC3532451 SCOPUS ID: 2-s2.0-84871695278 01/04/2013       11 Citations
  • Evidence for population-specific positive selection on immune genes of Anopheles gambiae. (Crawford JE, Bischoff E, Garnier T, Gneme A, Eiglmeier K, Holm I, Riehle MM, Guelbeogo WM, Sagnon N, Lazzaro BP, Vernick KD) G3 (Bethesda) 2012 Dec;2(12):1505-19 PMID: 23275874 PMCID: PMC3516473 SCOPUS ID: 2-s2.0-84883177832 01/01/2013       16 Citations
  • Outdoor-resting (exophilic) mosquitoes (Riehle MM, Guelbeogo WM, Eiglmeier K, Holm I, Bischoff E, Garnier T, Markianos K, Sagnon N, Vernick KD) Science 22 April 2011;332(6028):420-421 SCOPUS ID: 2-s2.0-79955388675 04/22/2011    
  • Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae. (Rottschaefer SM, Riehle MM, Coulibaly B, Sacko M, Niaré O, Morlais I, Traoré SF, Vernick KD, Lazzaro BP) PLoS Biol 2011 Mar;9(3):e1000600 PMID: 21408087 PMCID: PMC3050937 SCOPUS ID: 2-s2.0-79953725732 03/17/2011       58 Citations
  • A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites. (Riehle MM, Guelbeogo WM, Gneme A, Eiglmeier K, Holm I, Bischoff E, Garnier T, Snyder GM, Li X, Markianos K, Sagnon N, Vernick KD) Science 2011 Feb 04;331(6017):596-8 PMID: 21292978 PMCID: PMC3065189 SCOPUS ID: 2-s2.0-79551636620 02/05/2011       108 Citations
  • Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species. (Mitri C, Jacques JC, Thiery I, Riehle MM, Xu J, Bischoff E, Morlais I, Nsango SE, Vernick KD, Bourgouin C) PLoS Pathog 2009 Sep;5(9):e1000576 PMID: 19750215 PMCID: PMC2734057 SCOPUS ID: 2-s2.0-70349661228 09/15/2009       95 Citations
  • Anopheles gambiae APL1 is a family of variable LRR proteins required for Rel1-mediated protection from the malaria parasite, Plasmodium berghei. (Riehle MM, Xu J, Lazzaro BP, Rottschaefer SM, Coulibaly B, Sacko M, Niare O, Morlais I, Traore SF, Vernick KD) PLoS One 2008;3(11):e3672 PMID: 18989366 PMCID: PMC2577063 SCOPUS ID: 2-s2.0-56649115780 11/08/2008       62 Citations
  • A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae. (Riehle MM, Markianos K, Lambrechts L, Xia A, Sharakhov I, Koella JC, Vernick KD) Malar J 2007 Jul 06;6:87 PMID: 17612409 PMCID: PMC1936428 SCOPUS ID: 2-s2.0-34547621933 07/07/2007       21 Citations
  • Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. (Riehle MM, Markianos K, Niaré O, Xu J, Li J, Touré AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traoré SF, Vernick KD) Science 2006 Apr 28;312(5773):577-9 PMID: 16645095 SCOPUS ID: 2-s2.0-33646250928 04/29/2006       222 Citations
  • Anopheles gambiae genome reannotation through synthesis of ab initio and comparative gene prediction algorithms. (Li J, Riehle MM, Zhang Y, Xu J, Oduol F, Gomez SM, Eiglmeier K, Ueberheide BM, Shabanowitz J, Hunt DF, Ribeiro JM, Vernick KD) Genome Biol 2006;7(3):R24 PMID: 16569258 PMCID: PMC1557760 SCOPUS ID: 2-s2.0-33745026660 03/30/2006       21 Citations
  • Molecular genetics of mosquito resistance to malaria parasites. (Vernick KD, Oduol F, Lazzaro BP, Glazebrook J, Xu J, Riehle M, Li J) Curr Top Microbiol Immunol 2005;295:383-415 PMID: 16265899 SCOPUS ID: 2-s2.0-24144496226 11/04/2005       24 Citations
  • Differential Patterns of Gene Expression and Gene Complement in Laboratory-Evolved Lines of E. coli. (Riehle MM, Bennett AF, Long AD) Integr Comp Biol 2005 Jun;45(3):532-8 PMID: 21676798 SCOPUS ID: 2-s2.0-22844445679 06/01/2005       10 Citations
  • Changes in gene expression following high-temperature adaptation in experimentally evolved populations of E. coli. (Riehle MM, Bennett AF, Long AD) Physiol Biochem Zool 2005;78(3):299-315 PMID: 15887077 SCOPUS ID: 2-s2.0-19944422716 05/12/2005       20 Citations
  • Evolutionary changes in heat-inducible gene expression in lines of Escherichia coli adapted to high temperature. (Riehle MM, Bennett AF, Lenski RE, Long AD) Physiol Genomics 2003 Jun 24;14(1):47-58 PMID: 12672900 SCOPUS ID: 2-s2.0-0041625721 04/04/2003       73 Citations
  • Genetic architecture of thermal adaptation in Escherichia coli. (Riehle MM, Bennett AF, Long AD) Proc Natl Acad Sci U S A 2001 Jan 16;98(2):525-30 PMID: 11149947 PMCID: PMC14620 SCOPUS ID: 2-s2.0-0035895278 01/10/2001       211 Citations
  • Global gene expression profiling in Escherichia coli K12. The effects of integration host factor. (Arfin SM, Long AD, Ito ET, Tolleri L, Riehle MM, Paegle ES, Hatfield GW) J Biol Chem 2000 Sep 22;275(38):29672-84 PMID: 10871608 SCOPUS ID: 2-s2.0-0034703060 06/29/2000       225 Citations
  • Cell-cycle regulated expression of Rap1 in regenerating liver. (Cruise JL, Rafferty MP, Riehle MM) Biochem Biophys Res Commun 1997 Jan 23;230(3):578-81 PMID: 9015365 SCOPUS ID: 2-s2.0-0031584079 01/23/1997       1 Citation
    • Last update: 04/16/2023