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Brucella: functional genomics and host-pathogen interactions. Anim Health Res Rev 2006 Jun-Dec;7(1-2):1-11

Date

03/29/2007

Pubmed ID

17389050

DOI

10.1017/S146625230700117X

Scopus ID

2-s2.0-34447509539   24 Citations

Abstract

Brucellosis is a zoonotic disease caused by a number of Brucella species and is characterized by chronic macrophage infection. However, genes that may contribute to intracellular survival of the Brucella species are not well studied. This review presents, first, genomic islands that are present or absent in various Brucella species that may help establish Brucella infection and survival strategies. Second, the alteration in macrophage transcription by Brucella to permit its long-term survival within this hostile intracellular environment. A large number of macrophage gene transcripts are altered following Brucella infection indicating that Brucella is not a silent invader of host cells. Macrophage transcript levels associated with inflammation, apoptosis, signal transduction and vesicular intracellular trafficking are altered during Brucella infection, and likely contribute to intracellular survival of Brucella. Lastly, the host-pathogen interaction events associated with Brucella infection in living mice visualized in real-time using biophotonic imaging. Mice are often used to evaluate Brucella infections; however, Brucella dissemination and pathogenesis is poorly understood in mice. Biophotonic imaging of Brucella infections revealed sites of bacterial localization similar to human infections and different patterns of infection by attenuated or virulent Brucella.

Author List

Rajashekara G, Eskra L, Mathison A, Petersen E, Yu Q, Harms J, Splitter G

Author

Angela Mathison PhD Assistant Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Apoptosis
Biological Assay
Brucella
Brucellosis
Disease Models, Animal
Macrophages
Mice
Signal Transduction
Species Specificity
Virulence