TS+OCD-like neuropotentiated mice are supersensitive to seizure induction. Neuroreport 2000 Jul 14;11(10):2335-8
Date
08/03/2000Pubmed ID
10923696DOI
10.1097/00001756-200007140-00053Scopus ID
2-s2.0-0034647950 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Seizures can be induced by systemic dopamine D1 receptor agonists or by cortical-limbic neurostimulation non-selectively. Seizures are also often associated with tics and compulsions, which likewise involve cortical-limbic hyperactivity. To determine if selective potentiation of cortical-limbic D1 receptor-expressing (D1+) neurons increases seizure susceptibility, we administered pentylenetetrazole (PTZ) to mice that express a neuropotentiating transgene only in a glutamatergic, cortical-limbic subset of D1+ neurons (D1CT-7 line). These mice exhibited increased PTZ-dependent seizure incidence, onset rate and intensity. Because D1CT-7 mice also exhibit tic+compulsion-like behaviors, this implies that glutamatergic hyperactivity induced by cortical-limbic D1+ neuropotentiation facilitates not only epilepsy but also tics and compulsions. This suggests a dopamine-regulated glutamatergic basis for all three states and may explain why they often co-exist in humans.
Author List
Campbell KM, Veldman MB, McGrath MJ, Burton FHAuthor
Matthew B. Veldman PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCerebral Cortex
Disease Models, Animal
Humans
Limbic System
Male
Mice
Mice, Inbred BALB C
Mice, Transgenic
Models, Neurological
Neurons
Obsessive-Compulsive Disorder
Pentylenetetrazole
Pyramidal Cells
Seizures
Somatosensory Cortex
Tourette Syndrome
