Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab 2018 Oct;29(10):723-735
Date
08/29/2018Pubmed ID
30150136Pubmed Central ID
PMC6151151DOI
10.1016/j.tem.2018.08.004Scopus ID
2-s2.0-85052075104 (requires institutional sign-in at Scopus site) 84 CitationsAbstract
Salt-inducible kinases (SIKs) represent a subfamily of AMP-activated protein kinase (AMPK) family kinases. Initially named because SIK1 (the founding member of this kinase family) expression is regulated by dietary salt intake in the adrenal gland, it is now apparent that a major biological role of these kinases is to control gene expression in response to extracellular cues that increase intracellular levels of cAMP. Here, we review four physiologically relevant examples of how cAMP signaling impinges upon SIK cellular function. By focusing on examples of cAMP-mediated SIK regulation in gut myeloid cells, bone, liver, and skin, we highlight recent advances in G protein-coupled receptor (GPCR) signal transduction. New knowledge regarding the role of SIKs in GPCR signaling has led to therapeutic applications of novel small molecule SIK inhibitors.
Author List
Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HMAuthor
Melissa Wein MD Assistant Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AMP-Activated Protein KinasesHumans
Protein Kinase Inhibitors
Protein Kinases
Receptors, G-Protein-Coupled
Signal Transduction
